Evidence map›Paper›PMID 33630018›Full record

ArticleAnesthesiology2021

Opioid-free Anesthesia: Time to Regain Our Balance.

Evan D Kharasch, J David Clark

Registry-linked trialAbstract read
In one paragraph

Article in Anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05446623 (Comparative Study of General Anesthesia With or Without Opioid on the Cardiac Index During Total Hip Arthroplasty), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05446623 phase2 / phase3completednot on this map

Comparative Study of General Anesthesia With or Without Opioid on the Cardiac Index During Total Hip Arthroplasty

TypeinterventionalSponsorCentre Hospitalier de MontaubanRan2021 to 2024Enrolled120ConditionsHip Arthropathy, Hip DiseaseArmsDexmedetomidine, Sufentanil
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  20. Opioid-free anesthesia in research and practice: so near yet so far!Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Evan D Kharasch
J David Clark

Funding

OPTIMIZING OUTPATIENT ANESTHESIA: IMPROVING ANALGESIA AND REDUCING OPIOID MISADVENTURER01DA042985 · NIDA · WASHINGTON UNIVERSITY · PI KHARASCH, EVAN D. · 2017 to 2021
$2.2M
Genetics and Gene X Environment Interactions during Opioid AdministrationI01BX000881 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI CLARK, DAVID J. · 2011 to 2019
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BLRD VA I01 BX000881NIDA NIH HHS R01 DA042985
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Analgesics, OpioidAnesthesiaHumansPostoperative PainAnalgesics, Opioid

Identifiers

PMID33630018
PMCPMC7946714

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.