Evidence map›Paper›PMID 33629939›Full record

ArticleJournal of the American Association for Laboratory Animal Science : JAALAS2021

Evaluation of In-cage Filter Paper as a Replacement for Sentinel Mice in the Detection of Murine Pathogens.

Kathryn A O'Connell, Gabor J Tigyi, Robert S Livingston, Daniel L Johnson, David J Hamilton

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Journal of the American Association for Laboratory Animal Science : JAALAS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Evaluation of Direct Colony Sampling Compared with Sentinel-Free Soiled Bedding Testing for Murine Quarantine Programs.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  7. Rodent Pathogen Detection via Testing of Soiled Nesting Material.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  8. Improved Detection of Murine Pathogens Using Sentinel-Free Media Compared to Live Animal Sampling.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  9. Guidance on Establishing Health Monitoring Panels for Laboratory Mice to Reflect Contemporary Pathogen Prevalence.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. A Cross-sectional Survey on Rodent Environmental Health Monitoring Practices: Benchmarking, Associations, and Barriers.Journal of the American Association for Laboratory Animal Science : JAALAS · 2023
    Article
  14. Article
  15. Confirmation of Pathogen 'Burnout' in Mouse Colonies with Previous Evidence of Infection with Parvovirus and Rotavirus.Journal of the American Association for Laboratory Animal Science : JAALAS · 2022
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kathryn A O'ConnellDepartments of Comparative Medicine, University of Tennessee Health Science Center, Memphis, Tennessee;, Email: koconne7@uthsc.edu.
Gabor J TigyiDepartments of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.
Robert S LivingstonIDEXX BioAnalytics, Columbia, Missouri.
Daniel L JohnsonDepartment of Molecular Bioinformatics Core, University of Tennessee Health Science Center, Memphis, Tennessee.
David J HamiltonDepartments of Comparative Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
University of Tennessee Health Science Center · US

Funding

IND-Enabling Preclinical Development of a New RadiomitigatorU01AI107331 · NIAID · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI TIGYI, GABOR J · 2013 to 2018
$2.9M
NIAID NIH HHS U01 AI107331
6 · The paper itself

Abstract

Recent studies have evaluated alternatives to the use of live animals in colony health monitoring. Currently, an alternative method that is suitable for all rack types and that has been verified to detect the infectious agents most commonly excluded from mouse colonies is unavailable. We compared the use of filter paper placed on the inside floor of mouse cages to the traditional use of sentinel mice in the detection of several prevalent murine pathogens including mouse hepatitis virus (MHV), murine norovirus (MNV), minute virus of mice (MVM), mouse parvovirus (MPV), Theiler murine encephalomyelitis virus (TMEV),

Indexed as

Housing, AnimalPaperVirusesAnimalsBacterial InfectionsMiceMice, Inbred ICRParvoviridae InfectionsRodent DiseasesSentinel SurveillanceVirus Diseases

Identifiers

PMID33629939
PMCPMC7974814
OpenAlexW3132655198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.