Evidence map›Paper›PMID 33629655›Full record

ArticleeLife2021

A Non-stop identity complex (NIC) supervises enterocyte identity and protects from premature aging.

Neta Erez, Lena Israitel, Eliya Bitman-Lotan, Wing H Wong, Gal Raz, Dayanne V Cornelio-Parra, Salwa Danial, Na'ama Flint Brodsly, Elena Belova, Oksana Maksimenko and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Peculiarities of theInternational journal of molecular sciences · 2025
    Article
  2. Article
  3. The Molecular Architecture of the Nuclear Basket.bioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Review
  6. GermlineInternational journal of molecular sciences · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Neta ErezRappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Lena IsraitelRappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Eliya Bitman-LotanRappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Wing H WongDivision of Pediatric Hematology and Oncology, Washington University, Saint-Louis, United States.
Gal RazRappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Dayanne V Cornelio-ParraDepartment of Genetics, Developmental & Evolutionary Biology, School of Biological and Chemical Sciences University of Missouri, Kansas City, United States.
Salwa DanialRappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Na'ama Flint BrodslyRappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Elena BelovaDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russian Federation.
Oksana MaksimenkoDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russian Federation.
Pavel GeorgievDepartment of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, Moscow, Russian Federation.
Todd DruleyDivision of Pediatric Hematology and Oncology, Washington University, Saint-Louis, United States.
Ryan D MohanDepartment of Genetics, Developmental & Evolutionary Biology, School of Biological and Chemical Sciences University of Missouri, Kansas City, United States.ORCID 0000-0002-7624-4605
Amir OrianRappaport Research Institute and Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-8521-1661
Technion – Israel Institute of Technology · ILInstitute of Gene Biology · RUUniversity of Missouri–Kansas City · USWashington University in St. Louis · US

Funding

Transcription regulation in chromatinR35GM118068 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI JERRY L WORKMAN · 2016 to 2026
$4.2M
NIGMS NIH HHS R35 GM118068
6 · The paper itself

Abstract

A hallmark of aging is loss of differentiated cell identity. Aged

Indexed as

AgingAging, PrematureAnimalsDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsEnterocytesFemaleMalePhenotypeProteomeDrosophila ProteinsProteomeagingcell biologycell identitydevelopmental biologyD. melanogastergene regulationgutubiquitinUSP22/ Non-stop

Identifiers

PMID33629655
PMCPMC7936876
OpenAlexW3132932607

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.