ArticleThe plant genome2021
Population genetics and genome-wide association studies provide insights into the influence of selective breeding on genetic variation in lettuce.
Article in The plant genome, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Major Quantitative Trait Loci Control Low-Temperature Germination in Lettuce.Life (Basel, Switzerland) · 2026Article
- Modern approaches and future prospects in lettuce breeding for controlled environment agriculture.Frontiers in plant science · 2026Review
- Unraveling the variation, phylogeny, and taxonomy of Lactuca spp. for germplasm management and breeding.Planta · 2025Review
- Breeding for delayed bolting decelerated the circadian clock in cultivated lettuce.The New phytologist · 2025Article
- Genome-wide association studies in lettuce reveal the interplay of seed age, color, and germination under high temperatures.Scientific reports · 2025Article
- Genetic basis of phenotypic diversity inFrontiers in genetics · 2025Article
- Unveiling the Genetic Diversity and Demographic History ofPlants (Basel, Switzerland) · 2024Article
- Genetic Diversity and Evaluation of Agro-Morphological Traits in Lettuce Core Collection.Plants (Basel, Switzerland) · 2024Article
- Studies of genetic diversity and genome-wide association for vitamin C content in lettuce (Lactuca sativa L.) using high-throughput SNP arrays.The plant genome · 2024Article
- DNA methylation variations underlie lettuce domestication and divergence.Genome biology · 2024Article
- Low frequency of the wild-type freezing-tolerance LsCBF7 allele among lettuce population suggests a negative selection during domestication and breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genome-wide association study of salt tolerance at the seed germination stage in lettuce.PloS one · 2024Article
- Association Mapping and Expression Analysis of the Genes Involved in the Wood Formation of Poplar.International journal of molecular sciences · 2023Article
- Development and application of Single Primer Enrichment Technology (SPET) SNP assay for population genomics analysis and candidate gene discovery in lettuce.Frontiers in plant science · 2023Article
- Population structure analysis to explore genetic diversity and geographical distribution characteristics of cultivated-type tea plant in Guizhou Plateau.BMC plant biology · 2022Article
- Genome-wide core sets of SNP markers and Fluidigm assays for rapid and effective genotypic identification of Korean cultivars of lettuce (Horticulture research · 2022Article
- Genetic diversity using biochemical, physiological, karyological and molecular markers ofFrontiers in genetics · 2022Article
- Integrating Genomic and Phenomic Approaches to Support Plant Genetic Resources Conservation and Use.Plants (Basel, Switzerland) · 2021Review
- Population genetics and genome-wide association studies provide insights into the influence of selective breeding on genetic variation in lettuce.The plant genome · 2021Article
- QTL Analysis of Stem Elongation and Flowering Time in Lettuce Using Genotyping-by-Sequencing.Genes · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genetic diversity is an important resource in crop breeding to improve cultivars with desirable traits. Selective breeding can lead to a reduction of genetic diversity. However, our understanding on this subject remains limited in lettuce (Lactuca sativa L.). Genotyping-by-sequencing (GBS) can provide a reduced version of the genome as a cost-effective method to identify genetic variants across the genome. We genotyped a diverse set of 441 lettuce accessions using the GBS method. Phylogenetic and population genetic analyses indicated substantial genetic divergence among four horticultural types of lettuce: butterhead, crisphead, leaf, and romaine. Genetic-diversity estimates between and within the four types indicated that the crisphead type was the most differentiated from other types, whereas its population was the most homogenous with the slowest linkage disequilibrium (LD) decay among the four types. These results suggested that crisphead lettuces had relatively less genetic variation across the genome as well as low gene flow from other types. We identified putative selective sweep regions that showed low genetic variation in the crisphead type. Genome-wide association study (GWAS) and quantitative trait loci (QTL) analyses provided evidence that these genomic regions were, in part, associated with delayed bolting, implicating the positive selection of delayed bolting in reducing variation. Our findings enhance the current understanding of genetic diversity and the impacts of selective breeding on patterning genetic variation in lettuce.
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