Evidence map›Paper›PMID 33629203›Full record

ReviewClinical rheumatology2021

Adalimumab-induced sarcoidosis-like reaction involving oral cavity in rheumatoid arthritis: a case-based review.

Carla Isabelly Rodrigues-Fernandes, Cesar Augusto Migliorati, Luiz Alcino Monteiro Gueiros, Thayná Melo de Lima Morais, Pablo Agustin Vargas, Oslei Paes de Almeida, Márcio Ajudarte Lopes, Alan Roger Santos-Silva

Abstract readCase ReportsReview
PubMed Publisher
In one paragraph

Review in Clinical rheumatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Carla Isabelly Rodrigues-FernandesOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. carla.rodrigues212@gmail.com.ORCID http://orcid.org/0000-0002-1290-6235
Cesar Augusto MiglioratiDepartment of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA.ORCID https://orcid.org/0000-0002-2535-2606
Luiz Alcino Monteiro GueirosOral Medicine Unit, Department of Clinic and Preventive Dentistry, Federal University of Pernambuco, Recife, Brazil.ORCID https://orcid.org/0000-0003-4979-4318
Thayná Melo de Lima MoraisOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-2997-8016
Pablo Agustin VargasOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1840-4911
Oslei Paes de AlmeidaOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2002-8003
Márcio Ajudarte LopesOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-6677-0065
Alan Roger Santos-SilvaOral Diagnosis Department, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-2040-6617
Universidade Estadual de Campinas (UNICAMP) · BRUniversidade Federal de Pernambuco · BRUniversity of Florida · US

Funding

Coordination for the Improvement of Higher Education Personnel (CAPES) 001
6 · The paper itself

Abstract

Drug-induced sarcoidosis-like reaction (DISR) is a condition almost indistinguishable from sarcoidosis, both clinically and microscopically, consisting of granulomatous tissue reaction associated with a specific therapy. Commonly affected sites are the lungs, hilar lymph nodes, and skin. This report aimed to describe a very uncommon case of DISR with an unique involvement of the oral cavity. A 63-year-old female with a history of rheumatoid arthritis, who was treated with a TNF-α antagonist (adalimumab), presented multiple ulcerative nodules on the hard palate. Laboratory tests and imaging studies failed to show any other alterations. The biopsy specimen demonstrated multiple noncaseating granulomas. Histochemical reactions were negative for acid-fast bacilli and fungi, and immunohistochemical assessment highlighted the presence of normal lymphocytes and histiocytes. With the diagnosis of DISR, adalimumab was discontinued, and complete clinical resolution of the lesions was achieved after 14 months. Although uncommon, DISR should be considered in differential diagnoses of oral granulomatous reactions, especially in cases where the patient is being treated with TNF-α antagonists.

Indexed as

Arthritis, RheumatoidSarcoidosisAdalimumabFemaleHumansMiddle AgedMouthTumor Necrosis Factor-alphaAdalimumabTumor Necrosis Factor-alphaOral cavityRheumatoid arthritisSarcoid-like reactionSarcoidosis-like reactionTNF-α antagonist

Identifiers

PMID33629203
OpenAlexW3132717911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.