Evidence map›Paper›PMID 33629195›Full record

ReviewBasic research in cardiology2021

Does remote ischaemic conditioning reduce inflammation? A focus on innate immunity and cytokine response.

Lucie Pearce, Sean M Davidson, Derek M Yellon

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Basic research in cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lucie PearceThe Hatter Cardiovascular Institute, 67 Chenies Mews, London, WC1E 6HX, UK.
Sean M DavidsonThe Hatter Cardiovascular Institute, 67 Chenies Mews, London, WC1E 6HX, UK.
Derek M YellonThe Hatter Cardiovascular Institute, 67 Chenies Mews, London, WC1E 6HX, UK. d.yellon@ucl.ac.uk.ORCID http://orcid.org/0000-0001-7791-9320
Institute of Cancer Research · GB

Funding

British Heart Foundation PG/19/51/34493NIHR-BRC BRC233/CM/SD/101320The Hatter Foundation -
6 · The paper itself

Abstract

The benefits of remote ischaemic conditioning (RIC) have been difficult to translate to humans, when considering traditional outcome measures, such as mortality and heart failure. This paper reviews the recent literature of the anti-inflammatory effects of RIC, with a particular focus on the innate immune response and cytokine inhibition. Given the current COVID-19 pandemic, the inflammatory hypothesis of cardiac protection is an attractive target on which to re-purpose such novel therapies. A PubMed/MEDLINE™ search was performed on July 13th 2020, for the key terms RIC, cytokines, the innate immune system and inflammation. Data suggest that RIC attenuates inflammation in animals by immune conditioning, cytokine inhibition, cell survival and the release of anti-inflammatory exosomes. It is proposed that RIC inhibits cytokine release via a reduction in nuclear factor kappa beta (NF-κB)-mediated NLRP3 inflammasome production. In vivo, RIC attenuates pro-inflammatory cytokine release in myocardial/cerebral infarction and LPS models of endotoxaemia. In the latter group, cytokine inhibition is associated with a profound survival benefit. Further clinical trials should establish whether the benefits of RIC in inflammation can be observed in humans. Moreover, we must consider whether uncomplicated MI and elective surgery are the most suitable clinical conditions in which to test this hypothesis.

Indexed as

Immunity, InnateIschemic Preconditioning, MyocardialAnimalsCell SurvivalCOVID-19CytokinesExtracellular VesiclesHumansImmunity, HumoralInflammationMyocardial Reperfusion InjuryCytokinesCytokinesInflammationMyocardial infarctionRemote ischaemic conditioning

Identifiers

PMID33629195
PMCPMC7904035
OpenAlexW3129870669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.