ArticleMolecular genetics and genomics : MGG2021
Causal associations of waist circumference and waist-to-hip ratio with type II diabetes mellitus: new evidence from Mendelian randomization.
Article in Molecular genetics and genomics : MGG, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A Bayesian network model of new-onset diabetes in older Chinese: The Guangzhou biobank cohort study.Frontiers in endocrinology · 2022Trial
- Characterizing trajectories of diabetes-related health parameters before diabetes diagnosis in diabetes subtypes: analysis of a 20-year long prospective cohort study in Sweden.Cardiovascular diabetology · 2025Article
- Article
- Accuracy of novel anthropometric indices for assessing the risk for progression of prediabetes to diabetes; 13 years of results from Isfahan Cohort Study.Archives of endocrinology and metabolism · 2024Article
- Healthy Lifestyle Score and Glycemic Control in Type 2 Diabetes Mellitus Patients: A City-Wide Survey in China.Healthcare (Basel, Switzerland) · 2023Article
- Article
- Association of IgG N-glycomics with prevalent and incident type 2 diabetes mellitus from the paradigm of predictive, preventive, and personalized medicine standpoint.The EPMA journal · 2023Article
- Data mining approaches for type 2 diabetes mellitus prediction using anthropometric measurements.Journal of clinical laboratory analysis · 2023Article
- Causal relationships between telomere length and liver disease: a Mendelian randomization study.Frontiers in genetics · 2023Article
- Association between systemic immune-inflammatory index and diabetes mellitus: mediation analysis involving obesity indicators in the NHANES.Frontiers in public health · 2023Article
- Improving Machine Learning Diabetes Prediction Models for the Utmost Clinical Effectiveness.Journal of personalized medicine · 2022Article
- Lower functional hippocampal connectivity in healthy adults is jointly associated with higher levels of leptin and insulin resistance.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Causal relationship between particulate matter 2.5 and hypothyroidism: A two-sample Mendelian randomization study.Frontiers in public health · 2022Article
- The Association of Waist Circumference and the Risk of Deep Vein Thrombosis.International journal of general medicine · 2021Article
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Authors and funding
13 authors.
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Abstract
Type II diabetes mellitus (T2DM) is a metabolic disease with high incidence, which has seriously affected human life and health. The associations among waist circumference (WC), waist-to-hip ratio (WHR), and T2DM were discovered in observational studies. However, the causality of these associations still remains unknown. The present study aims to apply two-sample Mendelian randomization (TSMR) using genetic variants as instrumental variables (IVs) to evaluate the causality among WC, WHR, and T2DM. The participants were from three independent studies in genome-wide association studies (GWAS) datasets, which included 127,997 Europeans for WC, 73,137 Europeans for WHR and 659,316 Europeans for T2DM. Furthermore, 16 were associated WC SNPs and eight were associated WHR SNPs as instrument variables were selected for TSMR using P < 5 × 10
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