ArticleClinical oral investigations2021
Application of optical coherence tomography to study the structural features of oral mucosa in biopsy tissues of oral dysplasia and carcinomas.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Potential use of optical coherence tomography in oral potentially malignant disorders: in-vivo case series study.BMC oral health · 2023Trial
- Volumetric Imaging of Ex Vivo Oral Mucosa Specimens with Multi-Scale Wide Field-of-View Optical Coherence Tomography/Microscopy in Near-Infrared-II Window.Diagnostics (Basel, Switzerland) · 2026Article
- Diagnostic accuracy of optical coherence tomography for early oral cancer detection: A systematic review.Imaging science in dentistry · 2026Review
- Optical Coherence Tomography for Invasive Oral Squamous Cell Carcinoma: Diagnostic Accuracy and Grade- and Subsite-Associated Imaging Features.Journal of clinical medicine · 2026Article
- Quantitative assessment of biomechanical changes in oral lesions at different cancerous stages using optical coherence elastography.Quantitative imaging in medicine and surgery · 2025Article
- Advancing Non-Invasive Diagnosis of Oral Epithelial Dysplasia: Comparative Insights from In Vivo Optical Coherence Tomography and Histopathology.Journal of clinical medicine · 2025Article
- Critical review of OCT in clinical practice for the assessment of oral lesions.Frontiers in oncology · 2025Review
- Application of Targeted Optical Coherence Tomography in Oral Cancer: A Cross-Sectional Preliminary Study.Diagnostics (Basel, Switzerland) · 2024Article
- Enhancing Oral Cancer Detection: A Systematic Review of the Diagnostic Accuracy and Future Integration of Optical Coherence Tomography with Artificial Intelligence.Journal of clinical medicine · 2024Review
- Imaging Biomarkers of Oral Dysplasia and Carcinoma Measured with In Vivo Endoscopic Optical Coherence Tomography.Cancers · 2024Article
- Intraoperative Use of Wide-Field Optical Coherence Tomography to Evaluate Tissue Microstructure in the Oral Cavity and Oropharynx.JAMA otolaryngology-- head & neck surgery · 2023Article
- Site-Coded Oral Squamous Cell Carcinoma Evaluation by Optical Coherence Tomography (OCT): A Descriptive Pilot Study.Cancers · 2022Article
- A Systematic Review of Oral Biopsies, Sample Types, and Detection Techniques Applied in Relation to Oral Cancer Detection.Biotech (Basel (Switzerland)) · 2022Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveThis study aims to examine the ability of optical coherence tomography (OCT) to differentiate ex vivo epithelial structure of benign disorders, dysplastic, and oral squamous cell carcinoma (OSCC) in comparison with the structure of normal marginal mucosa of oral biopsies. As a secondary objective, we examined the inter- and intra-observer variations of OCT measurements of two calibrated assessors. MATERIALS AND
methodsOral biopsies (n = 44) were scanned using the swept source OCT (SSOCT) and grouped by pathology diagnosis to benign, dysplasia or carcinoma. Two trained and calibrated assessors scored on the five OCT variables: thickness of keratin layer (KL), epithelial layer (EL), homogeneity of lamina propria (LP), basement membrane integrity (BMI), and the degree of reflection of the epithelial layer (Ep Re). Chi-square tests and Fischer's exact method were used to compare the data.
resultsThe OCT images showed breached BM status in all the OSCC samples (100%). Epithelial reflection was noted to be hyper-reflective in all the OSCC and oral dysplasia samples (100%). An increase in KL in 66.67% of the OSCC and 100% of the oral dysplasia samples was found. EL was increased in all the OSCC samples (100%) and 85.72% of the oral dysplasias. Kappa values showed that there was very good agreement (over 0.7) when scoring individual parameters between the two assessors.
conclusionThe study showed that the BM status was a key parameter in the detection of SCC and for differentiating SCC from oral dysplasia or benign disorders. CLINICAL RELEVANCE: OCT is a non-invasive and non-radioactive adjunct diagnostic tool that can provide immediate results on the structure of oral mucosa. The BM status measured ex vivo was a key parameter in the detection of SCC and for differentiating SCC from oral dysplasia or benign disorders.
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