Evidence map›Paper›PMID 33629069›Full record

ArticleFunction (Oxford, England)2021

Heat Treatment Improves Hepatic Mitochondrial Respiratory Efficiency via Mitochondrial Remodeling.

Alex T Von Schulze, Fengyan Deng, Kelly N Z Fuller, Edziu Franczak, Josh Miller, Julie Allen, Colin S McCoin, Kartik Shankar, Wen-Xing Ding, John P Thyfault and 1 more

Open access · goldAbstract read
In one paragraph

Article in Function (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Diabetes, Protein Misfolding, and Heat Stress: Molecular Insights and Translational Perspectives.TH open : companion journal to thrombosis and haemostasis · 2026
    Review
  5. Sarcolipin but not phospholamban responds toFrontiers in physiology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Sexually dimorphic hepatic mitochondrial adaptations to exercise: a mini-review.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Review
  12. Acute exercise rapidly activates hepatic mitophagic flux.Journal of applied physiology (Bethesda, Md. : 1985) · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Alex T Von SchulzeMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Fengyan DengMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Kelly N Z FullerMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Edziu FranczakMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Josh MillerMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Julie AllenMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Colin S McCoinMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Kartik ShankarPediatrics, Section of Nutrition, The University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Wen-Xing DingPharmacology, Toxicology & Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160 USA.
John P ThyfaultMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
Paige C GeigerMolecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA.
University of Kansas Medical Center · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
RADx-UP: Improving the Response of Local Urban and Rural Communities to Disparities in Covid-19 TestingUL1TR002366 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Mario Castro, JAMES STEVEN LEEDER · 2017 to 2026
$44.3M
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett, Sean D. Taverna · 2017 to 2026
$27.6M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
Supplement for Google cloud build-outR24GM137786 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Alan Tackett · 2020 to 2026
$15.4M
Using PCORnet to Expand the DS-CONNECT Cohort Through Healthcare System Recruitment, Incorporating Electronic Health Records, and Assessing Self-DeterminationU54HD090216 · NICHD · UNIVERSITY OF KANSAS LAWRENCE · PI COLOMBO, JOHN A. · 2016 to 2020
$6.2M
Transgenics CoreP30GM118430 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2016 to 2020
$5.8M
Molecular Regulation of Cell Development and Differentiation Phase III COBREP30GM122731 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ABRAHAMSON, DALE R · 2017 to 2021
$5.6M
Divergence in Aerobic Capacity Drives Liver and Brain HealthR01DK121497 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI THYFAULT, JOHN P · 2019 to 2022
$2.2M
High Throughput Sequencing System for KUMC Genomics CoreS10OD021743 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SMITH, PETER G · 2017 to 2017
$493k
BLRD VA I01 BX002567NCATS NIH HHS UL1 TR002366NICHD NIH HHS U54 HD090216NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK121497NIGMS NIH HHS P20 GM103418NIGMS NIH HHS P20 GM121293NIGMS NIH HHS P30 GM118430NIGMS NIH HHS P30 GM122731NIGMS NIH HHS R24 GM137786NIH HHS S10 OD021743
6 · The paper itself

Abstract

Nonacholic fatty liver disease, or hepatic steatosis, is the most common liver disorder affecting the western world and currently has no pharmacologic cure. Thus, many investigations have focused on alternative strategies to treat or prevent hepatic steatosis. Our laboratory has shown that chronic heat treatment (HT) mitigates glucose intolerance, insulin resistance, and hepatic steatosis in rodent models of obesity. Here, we investigate the direct bioenergetic mechanism(s) surrounding the metabolic effects of HT on hepatic mitochondria. Utilizing mitochondrial proteomics and respiratory function assays, we show that one bout of acute HT (42°C for 20 min) in male C57Bl/6J mice (

Indexed as

Insulin ResistanceNon-alcoholic Fatty Liver DiseaseAnimalsBlood GlucoseMaleMiceMitochondriaBlood Glucoseautophagychaperone-mediated autophagyHSP72livermitochondrial organizationmitophagyredoxubiquitin

Identifiers

PMID33629069
PMCPMC7886620
OpenAlexW3123503642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.