ArticleMedicine and pharmacy reports2021
Young age and short duration of the disease are associated with more frequent relapses in inflammatory bowel disease patients.
Article in Medicine and pharmacy reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessing causality between inflammatory bowel diseases with frailty index and sarcopenia: a bidirectional Mendelian randomization study.European journal of medical research · 2024Pooled it
- Modifiable Factors Influencing Disease Flares in Inflammatory Bowel Disease: A Literature Overview of Lifestyle, Psychological, and Environmental Risk Factors.Journal of clinical medicine · 2025Review
- Higher disease activity of inflammatory bowel disease predisposes toTherapeutic advances in gastroenterology · 2025Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo evaluate the effects of the clinical predictors such as age, duration of disease, sex, and smoking on the frequency of relapses in IBD patients.
methodsThis study recruited 289 IBD (133 with CD and 156 with UC) patients. All were followed-up for 36 months for relapses of the disease. We defined as frequently relapsing (≥1/year) patients with at least one relapse per year and as infrequently relapsing those with less than one relapse per year (<1/year). We assessed the effect of the clinical predictors: age, duration of disease, sex, and smoking on the frequency of relapses in IBD patients.
resultsSixty-four (48.1%) of the CD patients were frequently relapsing and 69 (51.9%) were infrequently relapsing. There was a significant association between the age and the frequency of relapse (p=0.001; OR 0.964; 95% CI 0.941-0.987, p=0.002) and between the duration of the disease and frequency of relapse (p<0.001; OR 0.740, 95% CI 0.655-0.837, p<0.001). Seventy-two (46.2%) of the UC patients were frequently relapsing and 84 (53.8%) were infrequently relapsing. There was a significant association between the age and the frequency of relapse (p=0.001; OR 0.964, 95% CI 0.941-0.987, p=0.002) and between the duration of the disease and frequency of relapse (p<0.001; OR 0.740, 95% CI 0.655-0.837, p<0.001).
conclusionWe demonstrate in a relatively significant cohort of IBD patients that young age and short duration of the disease are associated with more frequent relapses.
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