Evidence map›Paper›PMID 33628813›Full record

Trial reportBioMed research international2021

The Prevalence of Thyroid Autoimmunity in Children with Developmental Dyslexia.

Roberta Degrandi, Flavia Prodam, Giulia Genoni, Giorgio Bellomo, Gianni Bona, Mara Giordano, Simonetta Bellone, Alice Monzani

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roberta DegrandiDivision of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.ORCID https://orcid.org/0000-0002-0432-7452
Flavia ProdamDepartment of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.ORCID https://orcid.org/0000-0001-9660-5335
Giulia GenoniPediatric and Neonatal Intensive Care Unit, Maggiore della Carità University Hospital, 28100 Novara, Italy.ORCID https://orcid.org/0000-0002-9280-3227
Giorgio BellomoClinical Chemistry Laboratory, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.ORCID https://orcid.org/0000-0003-4996-070X
Gianni BonaDivision of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.ORCID https://orcid.org/0000-0003-0611-7341
Mara GiordanoLaboratory of Human Genetics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.ORCID https://orcid.org/0000-0001-6686-4600
Simonetta BelloneDivision of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.ORCID https://orcid.org/0000-0001-8521-497X
Alice MonzaniDivision of Pediatrics, Department of Health Sciences, Università del Piemonte Orientale, 28100 Novara, Italy.ORCID https://orcid.org/0000-0002-6676-5773

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

methodsWe enrolled pediatric subjects with developmental dyslexia and, as a control group, healthy age- and sex-matched subjects without developmental dyslexia. Thyroid function was evaluated in subjects with developmental dyslexia measuring serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). Thyroid autoimmunity was evaluated in all subjects measuring antithyroid peroxidase (TPO-Ab) and antithyroglobulin (TG-Ab) antibodies. In subjects with developmental dyslexia, thyroid ultrasonography (US) was also performed.

resultsWe enrolled 51 subjects with developmental dyslexia (M : F = 39 : 12, mean age 12.4 ± 9 years) and 34 controls (M : F = 24 : 10, mean age 10.8 ± 4 years). TPO-Ab positivity was significantly higher in subjects with developmental dyslexia compared to controls (60.8% vs. 2.9%,

conclusionsWe found an extremely high prevalence of thyroid autoimmunity in children with developmental dyslexia. Further studies are needed to confirm our observations, but our findings may change the approach to this disorder and eventually lead to a systematic determination of thyroid autoimmunity in children with developmental dyslexia.

Indexed as

DyslexiaThyroiditis, AutoimmuneAdolescentAdultAutoantibodiesChildFemaleHumansMalePrevalenceThyroid Function TestsThyroid Hormonesanti-thyroglobulinAutoantibodiesThyroid Hormones

Identifiers

PMID33628813
PMCPMC7884110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.