Evidence map›Paper›PMID 33628800›Full record

ArticleBioMed research international2021

Expression of Nitric Oxide Synthase and Nitric Oxide Levels in Peripheral Blood Cells and Oxidized Low-Density Lipoprotein Levels in Saliva as Early Markers of Severe Dengue.

Harsha Hapugaswatta, Ruwani L Wimalasekara, Suharshi S Perera, Ranjan Premaratna, Kapila N Seneviratne, Nimanthi Jayathilaka

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In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Harsha HapugaswattaDepartment of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.ORCID https://orcid.org/0000-0001-5913-7632
Ruwani L WimalasekaraDepartment of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.ORCID https://orcid.org/0000-0002-1722-6634
Suharshi S PereraNorth Colombo Teaching Hospital, Ragama, Sri Lanka.ORCID https://orcid.org/0000-0002-5052-9637
Ranjan PremaratnaNorth Colombo Teaching Hospital, Ragama, Sri Lanka.ORCID https://orcid.org/0000-0002-6588-9467
Kapila N SeneviratneDepartment of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.ORCID https://orcid.org/0000-0001-5173-2998
Nimanthi JayathilakaDepartment of Chemistry, Faculty of Science, University of Kelaniya, Kelaniya, Sri Lanka.ORCID https://orcid.org/0000-0001-8741-3075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere dengue (SD), experienced by only a fraction of dengue patients, can be lethal. Due to the lack of early markers that can predict the evolution of SD, all dengue patients have to be monitored under hospital care. We discovered early oxidative stress markers of SD to identify patients who can benefit from early intervention before the symptoms appear.

methodsThe expression of inducible nitric oxide synthase (iNOS) in peripheral blood cells (PBC), nitric oxide (NO), and oxidized low-density lipoprotein (oxLDL) levels in plasma and saliva collected at early stages of dengue infection from 20 nonsevere dengue fever (DF) patients and 20 patients who later developed SD were analyzed in a retrospective nested case-control study.

resultsThe expression of iNOS is significantly (

conclusionsThese findings suggest that the expression of iNOS (73% sensitivity, 86% specificity) and plasma NO (96% sensitivity, 61% specificity at 22.3

Indexed as

Severe DengueAdolescentAdultBiomarkersCase-Control StudiesFemaleHumansLipoproteins, LDLMaleMiddle AgedNitric OxideNitric Oxide Synthase Type IIRetrospective StudiesSalivaSensitivity and SpecificityYoung AdultBiomarkersLipoproteins, LDLNitric OxideNitric Oxide Synthase Type IINOS2 protein, humanoxidized low density lipoprotein

Identifiers

PMID33628800
PMCPMC7889359

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.