Evidence map›Paper›PMID 33628792›Full record

SynthesisBioMed research international2021

A Systematic Review of Lymphangioleiomyomatosis on Diagnosis and Molecular Mechanism.

Xiaotong Dong, Lvcheng Jin, Ailan Wang, Liping Wu, Xintong Fan, Qian Hou, Tianbao Li, Ruilian Zhao, Yunxiang Zhang

RetractedAbstract readSystematic ReviewRetracted Publication
In one paragraph

Synthesis in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Multinodal Cervical Angiomyomatous Hamartoma.International journal of surgical pathology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xiaotong DongDepartment of Pathology, First Affiliated Hospital of Weifang Medical University, Weifang People's Hospital, Weifang 261041, China.
Lvcheng JinDepartment of Pathology, First Affiliated Hospital of Weifang Medical University, Weifang People's Hospital, Weifang 261041, China.
Ailan WangDepartment of Science, Qingdao Geneis Institute of Big Data Mining and Precision Medicine, Qingdao, China.
Liping WuDepartment of Respiratory, First Affiliated Hospital of Weifang Medical University, Weifang People's Hospital, Weifang 261041, China.
Xintong FanDepartment of Pathology, First Affiliated Hospital of Weifang Medical University, Weifang People's Hospital, Weifang 261041, China.
Qian HouDepartment of Pathology, First Affiliated Hospital of Weifang Medical University, Weifang People's Hospital, Weifang 261041, China.
Tianbao LiDepartment of Science, Qingdao Geneis Institute of Big Data Mining and Precision Medicine, Qingdao, China.
Ruilian ZhaoDepartment of General Practice, Affiliated Hospital of Weifang Medical University, Weifang 261031, China.ORCID https://orcid.org/0000-0003-3527-7870
Yunxiang ZhangDepartment of Pathology, First Affiliated Hospital of Weifang Medical University, Weifang People's Hospital, Weifang 261041, China.ORCID https://orcid.org/0000-0002-3073-9979

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveLymphangioleiomyomatosis (LAM) is a rare low-grade metastatic tumor; however, LAM patients were always found in young age with difficulty for diagnosis. Our study is aimed at observing the clinical characteristics of patients with lymphangiomatosis, including the clinical manifestations, imaging findings, histopathological features, and immunophenotype.

methodsWe did a systematic review on LAM/PLAM cases, especially on male cases, and collected the clinical features and molecular mechanisms of PLAM based on previous findings.

resultsDiagnosis criteria were summarized by combining CT scans, MRI, immunohistochemistry results, and gene sequencing results for effectively distinguishing between PLAM and similar diseases. Moreover, our study illustrated the molecular mechanism of PLAM as well as the signaling pathway involved in the disease initials. In addition, a male case was reported with differential diagnosis on the clinical manifestations, microscopic features, immunophenotypes, and genotypes.

conclusionOur review will definitely improve the understanding of diagnosis and treatment in PLAM cases.

Indexed as

LymphangioleiomyomatosisAdolescentAdultAgedDiagnosis, DifferentialFemaleHumansImmunohistochemistryLung NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedSignal TransductionTomography, X-Ray ComputedYoung Adult

Identifiers

PMID33628792
PMCPMC7892222

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.