SynthesisFrontiers in oncology2020
Predictive Factors for Positive Surgical Margins in Patients With Prostate Cancer After Radical Prostatectomy: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Pooled it
- Accuracy of the LaserSAFE technique for detecting positive surgical margins during robot-assisted radical prostatectomy: blind assessment and inter-rater agreement analysis.Histopathology · 2025Trial
- Preoperative dual-ROI mpMRI radiomics integrating intratumoral and periprostatic adipose tissue features with clinical factors for predicting positive surgical margins after radical prostatectomy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Article
- Robotic radical prostatectomy in kidney transplant recipients: A propensity-matched cohort study.BJUI compass · 2025Article
- Lesion-based grading system using clinicopathological and MRI features for predicting positive surgical margins in prostate cancer.Abdominal radiology (New York) · 2025Article
- Targeting All Multiple Magnetic Resonance Imaging Prostate Lesions Does Not Enhance Cancer Detection: Insights from the YAU Prostate Cancer Group.European urology open science · 2025Article
- Analysis of risk factors for positive margins in robot-assisted laparoscopic radical prostatectomy with Retzius-sparing (RS-RARP).World journal of surgical oncology · 2025Article
- Development of preoperative nomograms to predict the risk of overall and multifocal positive surgical margin after radical prostatectomy.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024Article
- An MRI-based grading system for preoperative risk estimation of positive surgical margin after radical prostatectomy.Insights into imaging · 2023Article
- Intravoxel incoherent motion predicts positive surgical margins and Gleason score upgrading after radical prostatectomy for prostate cancer.La Radiologia medica · 2023Article
- Risk-stratification system for preoperative evaluation.Journal of the Chinese Medical Association : JCMA · 2023Article
- A trend to minimize the radicality of surgery.Journal of the Chinese Medical Association : JCMA · 2023Article
- Multiparametric MRI-based nomograms in predicting positive surgical margins of prostate cancer after laparoscopic radical prostatectomy.Frontiers in oncology · 2022Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesPrevious studies have demonstrated that positive surgical margins (PSMs) were independent predictive factors for biochemical and oncologic outcomes in patients with prostate cancer (PCa). This study aimed to conduct a meta-analysis to identify the predictive factors for PSMs after radical prostatectomy (RP).
methodsWe selected eligible studies
resultsTwenty-seven studies including 50,014 patients with PCa were eligible for further analysis. The results showed that PSMs were significantly associated with preoperative prostate-specific antigen (PSA) (pooled SMD = 0.37; 95% CI: 0.31-0.43; P < 0.001), biopsy Gleason Score (<6/≥7) (pooled OR = 1.53; 95% CI:1.31-1.79; P < 0.001), pathological Gleason Score (<6/≥7) (pooled OR = 2.49; 95% CI: 2.19-2.83; P < 0.001), pathological stage (<T2/≥T3) (pooled OR = 3.90; 95% CI: 3.18-4.79; P < 0.001), positive lymph node (PLN) (pooled OR = 3.12; 95% CI: 2.28-4.27; P < 0.001), extraprostatic extension (EPE) (pooled OR = 4.44; 95% CI: 3.25-6.09; P < 0.001), and seminal vesicle invasion (SVI) (pooled OR = 4.19; 95% CI: 2,87-6.13; P < 0.001). However, we found that age (pooled SMD = 0.01; 95% CI: -0.07-0.10; P = 0.735), body mass index (BMI) (pooled SMD = 0.12; 95% CI: -0.05-0.30; P = 0.162), prostate volume (pooled SMD = -0.28; 95% CI: -0.62-0.05; P = 0.097), and nerve sparing (pooled OR = 0.90; 95% CI: 0.71-1.14; P = 0.388) had no effect on PSMs after RP. Besides, the findings in this study were found to be reliable by our sensitivity and subgroup analyses.
conclusionsPreoperative PSA, biopsy Gleason Score, pathological Gleason Score, pathological stage, positive lymph node, extraprostatic extension, and seminal vesicle invasion are independent predictors of PSMs after RP. These results may helpful for risk stratification and individualized therapy in PCa patients.
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