New cytotoxic compounds from the leaves of

Tayo I Famojuro, Taiwo O Elufioye, Olumayokun A Olajide, Michael Dybek, Adeboye Adejare

Abstract read

In one paragraph

Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tayo I FamojuroDepartment of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Taiwo O ElufioyeDepartment of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

Olumayokun A OlajideDepartment of Pharmacy, School of Applied Sciences, University of Huddersfield, West Yorkshire, England.

Michael DybekPhiladelphia College of Pharmacy, University of Sciences in Philadelphia, Philadelphia, PA 19104, USA.

Adeboye AdejarePhiladelphia College of Pharmacy, University of Sciences in Philadelphia, Philadelphia, PA 19104, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe incidence of multi-drug resistant cancer and the adverse effects associated with available chemotherapy have necessitated the search for new drug candidates. This study investigates the cytotoxic activity of MATERIALS AND

methodsColumn chromatography (CC) and preparative thin layer chromatography (PTLC) were used to isolate compounds. Structural elucidation was done by spectroscopic analysis. MTT assay was used to evaluate cytotoxicity of the compounds against three human adenocarcinoma cells, using methotrexate and dimethyl sulfoxide (DMSO) as positive and negative controls, respectively. CyQuant direct cell proliferation and caspase-3/7 green detection assays were used to investigate the dichloromethane fraction. IC

resultsFour new cytotoxic compounds, benthamianoate (2), benthamiacone (3), benthamianin (5) and benthamianol (6), and two known compounds, methyl gallate (1) and 2-methoxyacrylic acid (4) were identified. All the compounds were active with the new monoterpenoid characterized as benthamiacone exhibiting the highest activity (IC

conclusionThis study revealed potential cytotoxic compounds which are here reported for the first time from

Indexed as

A549BenthamiaconeCaesalpinia benthamianaCytotoxicityMCF-7PC3

Identifiers

PMID33628720

PMCPMC7885006

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.