ArticleProceedings of the National Academy of Sciences of the United States of America1988
Pattern of expression of glutamic acid decarboxylase mRNA in the developing rat brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 39 citations in OpenAlex.
- Mesomere-derived glutamate decarboxylase-expressing blastocoelar mesenchyme cells of sea urchin larvae.Biology open · 2014Article
- Glutamic acid decarboxylase of embryonic avian retina cells in culture: regulation by gamma-aminobutyric acid (GABA).Cellular and molecular neurobiology · 1991Article
- Cloning and primary structure of a human islet isoform of glutamic acid decarboxylase from chromosome 10.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Cloning, characterization, and autoimmune recognition of rat islet glutamic acid decarboxylase in insulin-dependent diabetes mellitus.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Molecular cloning of the mouse CCK gene: expression in different brain regions and during cortical development.Nucleic acids research · 1991Article
- Developmentally regulated expression of an exon containing a stop codon in the gene for glutamic acid decarboxylase.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The time and pattern of appearance of glutamic acid decarboxylase (glutamate decarboxylase; EC 4.1.1.15) (GAD) mRNA during the development of the rat brain were analyzed. RNA transfer blot analysis of poly(A)+ RNA from whole brain shows that a 3.7-kilobase transcript is the most abundant form of the message from embryonic day 15 (E15) through adulthood. By E15 this form is present at about 50% of its adult abundance relative to other poly(A)+ mRNA species. At birth the abundance is approximately the same as in the adult. In contrast, the enzyme activity level is only 8% of the adult level at birth and takes 3 weeks to reach adult levels. There are qualitative changes in GAD mRNA during development. Several large (7-9 kilobases) transcripts with strong homology to GAD are enriched in early developmental stages but are barely detectable in the adult. A nuclease protection assay shows a developmentally regulated heterogeneity in a coding portion of the mRNA.
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