ArticleProceedings of the National Academy of Sciences of the United States of America1988
Electrical stimulation in vivo increases the expression of proenkephalin mRNA and decreases the expression of prodynorphin mRNA in rat hippocampal granule cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 115 citations in OpenAlex.
- Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density.Journal of neuroscience research · 2019Article
- Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Poster communications.British journal of pharmacology · 1993Article
- Preproenkephalin promoter "cassette" confers brain expression and synaptic regulation in transgenic mice.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Regulation of proenkephalin A gene expression in aggregating fetal rat brain cells.Cellular and molecular neurobiology · 1991Article
- The role of immediate early genes in the stabilization of long-term potentiation.Molecular neurobiology · 1991Review
- Neuropeptide gene expression and neural activity: assessing a working hypothesis in nucleus caudalis and dorsal horn neurons expressing preproenkephalin and preprodynorphin.Cellular and molecular neurobiology · 1990Review
- Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Activity-dependent regulation of gene expression in muscle and neuronal cells.Molecular neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In situ hybridization histochemistry in combination with RNA blot techniques was used to study the regulation of opioid gene expression in rat hippocampus. By use of a prodynorphin cDNA probe, a strong hybridization signal was identified in the granule cell layer of the hippocampus. However, experiments using a proenkephalin cDNA probe revealed that the content of proenkephalin mRNA was considerably lower than that of prodynorphin mRNA. Following five brief trains of high-frequency electrical stimulation to the dentate gyrus, the proenkephalin mRNA content of the granule cells, measured 22 hr later, was substantially increased on the stimulated side. In contrast, levels of prodynorphin mRNA were markedly decreased ipsilateral to the stimulation site. These results were confirmed by RNA blot analysis of extracted mRNA. The decrease in prodynorphin mRNA content first became apparent between 4 and 7 hr after the end of stimulation. Distinct mechanisms, therefore, regulate the expression of proenkephalin mRNA and prodynorphin mRNA in rat hippocampus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.