ArticlePeerJ2021
Lower Locus Coeruleus MRI intensity in patients with late-life major depression.
Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Vagus nerve stimulation alters task-evoked pupillary responses in older but not younger adults: A single-blind active sham-controlled crossover trial.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The potential of neuromelanin-sensitive MRI in psychiatric disorders.Neuroscience applied · 2026Review
- Locus Coeruleus MR Measured Signal Intensity in Fibromyalgia Relative to Healthy Controls.European journal of pain (London, England) · 2025Article
- Regenerating Locus Coeruleus-Norepinephrine (LC-NE) Function: A Novel Approach for Neurodegenerative Diseases.Cell proliferation · 2025Review
- Age-related differences in locus coeruleus intensity across a demographically diverse sample.Neurobiology of aging · 2025Article
- Early Changes in the Locus Coeruleus in Mild Cognitive Impairment with Lewy Bodies.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Disrupted microsaccade responses in late-life depression.Scientific reports · 2025Article
- Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Exploring the Role of Locus Coeruleus in Alzheimer's Disease: a Comprehensive Update on MRI Studies and Implications.Current neurology and neuroscience reports · 2023Review
- Locus coeruleus neuromelanin accumulation and dissipation across the lifespan.bioRxiv : the preprint server for biology · 2023Article
- Rostral-middle locus coeruleus integrity and subjective cognitive decline in early old age.Journal of the International Neuropsychological Society : JINS · 2023Article
- Article
- Age-related differences in the functional topography of the locus coeruleus: implications for cognitive and affective functions.medRxiv : the preprint server for health sciences · 2023Article
- Structural and functional characterization of the locus coeruleus in young and late middle-aged individuals.Frontiers in neuroimaging · 2023Article
- Neuromelanin related ultra-high field signal intensity of the locus coeruleus differs between Parkinson's disease and controls.NeuroImage. Clinical · 2023Article
- How Is the Norepinephrine System Involved in the Antiepileptic Effects of Vagus Nerve Stimulation?Frontiers in neuroscience · 2021Review
- Altered oculomotor signatures of emotional conflict and valence processing in late-life depression.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe locus coeruleus (LC) is the major noradrenergic source in the central nervous system. Structural alterations in the LC contribute to the pathophysiology of different neuropsychiatric disorders, which may increase to a variable extent the likelihood of developing neurodegenerative conditions. The characterization of such alterations may therefore help to predict progression to neurodegenerative disorders. Despite the LC cannot be visualized with conventional magnetic resonance imaging (MRI), specific MRI sequences have been developed to infer its structural integrity.
methodsWe quantified LC signal Contrast Ratios (LCCRs) in late-life major depressive disorder (MDD) (
resultsLCCRs were lower in MDD compared to aMCI and HCs. While no effects of aMCI comorbidity were observed, lower LCCRs were specifically observed in patients taking serotonin/norepinephrine reuptake inhibitors (SNRIs).
conclusionOur results do not support the hypothesis that lower LCCRs characterize the different clinical groups that may eventually develop a neurodegenerative disorder. Conversely, our results were specifically observed in patients with late-life MDD taking SNRIs. Further research with larger samples is warranted to ascertain whether medication or particular clinical features of patients taking SNRIs are associated with changes in LC neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.