ArticleACS catalysis2020
A Widely Applicable Dual Catalytic System for Cross-Electrophile Coupling Enabled by Mechanistic Studies.
Article in ACS catalysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Advancing Drug Discovery through Academia-Industry Collaborations: Lessons from Merck Discovery Chemistry Partnerships.ACS central science · 2026Review
- Metal-Catalyzed Reductive Coupling of Aryl Halides beyond Premetalated Reagents or Metallic Reductants: Biaryl Formation.Chemical reviews · 2026Review
- Synthesis of Tetrakis(amino)ethylene-Derived Organic Reductants via Thermal Decomposition of Tris(amino)methanes.Organic letters · 2026Article
- Heterobenzyl Chlorides as Linchpins for C-H Arylation via Sequential C-H Chlorination/Cross-Electrophile Coupling.ACS catalysis · 2026Article
- Cross-Electrophile Coupling ofJournal of the American Chemical Society · 2026Article
- Synthesis of Substituted Benzo[1, 4]oxazine Derivatives from the Reaction of Trichloroacetonitrile-nitro Compound Adduct and 2-Iodophenol.Current organic synthesis · 2026Article
- Use of Electron-Transfer Mediators to Access Higher Electrochemical Current Densities in Ni-Catalyzed Cross-Electrophile Coupling.Journal of the American Chemical Society · 2025Article
- Cobalt-catalyzed reductive cross-coupling: a review.Molecular diversity · 2025Review
- Combining biocatalytic and radical retrosynthesis for efficient chemoenzymatic synthesis of natural products.Chemical Society reviews · 2025Review
- Ni/Ti Dual Catalyzed Cross-Electrophile Coupling Between Unactivated Alkyl Chlorides and Aryl Halides.ACS catalysis · 2025Article
- Cross-Electrophile Coupling to Form Sterically Hindered C(spJournal of the American Chemical Society · 2025Article
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Homogeneous Organic Reductant Based on 4,4'-Tetrahedron letters · 2024Article
- Effect of 6,6'-Substituents on Bipyridine-Ligated Ni Catalysts for Cross-Electrophile Coupling.ACS catalysis · 2024Article
- Formal Cross-Coupling of Amines and Carboxylic Acids to Form spJournal of the American Chemical Society · 2023Article
- High-Throughput Photo- and Electrochemical spACS medicinal chemistry letters · 2023Article
- Multimetallic-Catalyzed C-C Bond-Forming Reactions: From Serendipity to Strategy.Journal of the American Chemical Society · 2023Review
- Zinc-Free, Scalable Reductive Cross-Electrophile Coupling Driven by Electrochemistry in an Undivided Cell.ACS catalysis · 2022Article
- Homogeneous Organic Electron Donors in Nickel-Catalyzed Reductive Transformations.The Journal of organic chemistry · 2022Review
- Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes.Organic letters · 2022Article
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Authors and funding
5 authors.
Funding
Abstract
A dual catalytic system for cross-electrophile coupling reactions between aryl halides and alkyl halides that features a Ni catalyst, a Co cocatalyst, and a mild homogeneous reductant is described. Mechanistic studies indicate that the Ni catalyst activates the aryl halide, while the Co cocatalyst activates the alkyl halide. This allows the system to be rationally optimized for a variety of substrate classes by simply modifying the loadings of the Ni and Co catalysts based on the reaction product profile. For example, the coupling of aryl bromides and aryl iodides with alkyl bromides, alkyl iodides, and benzyl chlorides is demonstrated using the same Ni and Co catalysts under similar reaction conditions but with different optimal catalyst loadings in each case. Our system is tolerant of numerous functional groups and is capable of coupling heteroaryl halides, di-
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