ArticleProceedings of the National Academy of Sciences of the United States of America1988
Do exons code for structural or functional units in proteins?
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42 citing papers in PubMed, 146 citations in OpenAlex.
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- Tryptophanyl-tRNA synthetase Urzyme: a model to recapitulate molecular evolution and investigate intramolecular complementation.The Journal of biological chemistry · 2010Article
- Association of human cholesteryl ester transfer protein-TaqI polymorphisms with serum HDL cholesterol levels in a normolipemic Japanese rural population.Journal of epidemiology · 2002Article
- Cloning and characterization of the calreticulin gene from Ricinus communis L.Plant molecular biology · 1997Article
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- A relationship between GC content and coding-sequence length.Journal of molecular evolution · 1996Article
- Ferritin gene organization: differences between plants and animals suggest possible kingdom-specific selective constraints.Journal of molecular evolution · 1996Article
- How are close residues of protein structures distributed in primary sequence?Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Evolutionary relationships of the carbamoylphosphate synthetase genes.Journal of molecular evolution · 1995Article
- Isolation and characterization of the androgen-dependent mouse cysteine-rich secretory protein-3 (CRISP-3) gene.The Biochemical journal · 1995Article
- The elicitor-inducible alfalfa isoflavone reductase promoter confers different patterns of developmental expression in homologous and heterologous transgenic plants.The Plant cell · 1994Article
- Analysis of peptides from known proteins: clusterization in sequence space.Journal of molecular evolution · 1994Article
- The biology of perlecan: the multifaceted heparan sulphate proteoglycan of basement membranes and pericellular matrices.The Biochemical journal · 1994Review
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1 author at 1 institution in 1 country.
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Abstract
In considering the origin and evolution of proteins, the possibility that proteins evolved from exons coding for specific structure-function modules is attractive for its economy and simplicity but is not systematically supported by the available data. However, the number of correspondences between exons and units of protein structure-function that have so far been identified appears to be greater than expected by chance alone. The available data also show (i) that exons are fairly limited in size but are large enough to specify structure-function modules in proteins; (ii) that the position of introns for homologous domains in the same gene is reasonably stable, but there is also evidence for mechanisms that alter the position or existence of introns; and (iii) that it is possible that the observed relationship of exons to protein structure represents a degenerate state of an ancestral correspondence between exons and structure-function modules in proteins.
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