Evidence map›Paper›PMID 33628205›Full record

ArticleFrontiers in immunology2020

Developing a 3D B Cell Lymphoma Culture System to Model Antibody Therapy.

Russell Foxall, Priyanka Narang, Bridget Glaysher, Elin Hub, Emma Teal, Mark C Coles, Margaret Ashton-Key, Stephen A Beers, Mark S Cragg

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Review
  6. Article
  7. Goodbye flat lymphoma biology.FEBS letters · 2025
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Multiple Cell Cultures for MRI Analysis.International journal of molecular sciences · 2022
    Review
  18. Review
  19. Review
  20. Three-dimensional models: a novel approach for lymphoma research.Journal of cancer research and clinical oncology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Russell FoxallAntibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.
Priyanka NarangAntibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.
Bridget GlaysherCentre for Immunology and Infection, University of York, York, United Kingdom.
Elin HubCentre for Immunology and Infection, University of York, York, United Kingdom.
Emma TealAntibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.
Mark C ColesCentre for Immunology and Infection, University of York, York, United Kingdom.
Margaret Ashton-KeyAntibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.
Stephen A BeersAntibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.
Mark S CraggAntibody and Vaccine Group, Centre for Cancer Immunology, School of Cancer Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.
University of Southampton · GBUniversity of York · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Oxford · GB

Funding

Cancer Research UK 24721Cancer Research UK A25139Cancer Research UK A25171National Centre for the Replacement, Refinement and Reduction of Animals in Research NC/K000527/1
6 · The paper itself

Abstract

Diffuse large cell B cell lymphoma (DLBCL) accounts for approximately 30%-40% of all non-Hodgkin lymphoma (NHL) cases. Current first line DLBCL treatment results in long-term remission in more than 60% of cases. However, those patients with primary refractory disease or early relapse exhibit poor prognosis, highlighting a requirement for alternative therapies. Our aim was to develop a novel model of DLBCL that facilitates

Indexed as

Tumor MicroenvironmentAntineoplastic Agents, ImmunologicalCancer-Associated FibroblastsCell CommunicationCell Culture TechniquesCoculture TechniquesCytotoxicity, ImmunologicHumansLymphoma, Large B-Cell, DiffusePhagocytosisRituximabSpheroids, CellularTumor-Associated MacrophagesTumor Cells, CulturedAntineoplastic Agents, ImmunologicalRituximab3D co-culture modeladipocyte derived stem cellantibody therapycancer associated fibroblastdiffuse large B cell lymphomatumor associated macrophage

Identifiers

PMID33628205
PMCPMC7897703
OpenAlexW3127844961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.