Evidence map›Paper›PMID 33627874›Full record

ArticleNature2021

A multi-scale brain map derived from whole-brain volumetric reconstructions.

Christopher A Brittin, Steven J Cook, David H Hall, Scott W Emmons, Netta Cohen

Open access · greenAbstract read
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 127 citations in OpenAlex.

  1. Article
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  6. Physical contact reveals a hidden layer of cortical architecture.bioRxiv : the preprint server for biology · 2026
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  7. Science advances · 2026
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  10. From nematode to Nobel: How community-shared resources fueled the rise ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Nervous system-wide analysis of allScience advances · 2025
    Article
  16. Review
  17. Journal of biosciences · 2025
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Christopher A BrittinSchool of Computing, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-1143-554X
Steven J CookDepartment of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA.
David H HallDepartment of Neuroscience, Albert Einstein College of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-8459-9820
Scott W EmmonsDepartment of Genetics, Albert Einstein College of Medicine, New York, NY, USA.
Netta CohenSchool of Computing, University of Leeds, Leeds, UK. N.Cohen@leeds.ac.uk.ORCID http://orcid.org/0000-0002-1633-3315
Albert Einstein College of Medicine · USUniversity of Leeds · GB

Funding

Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
CENTER FOR CAENORHABDITIS ELGANS ANATOMYR24RR012596 · NCRR · YESHIVA UNIVERSITY · PI HALL, DAVID H. · 1998 to 2011
$8.0M
Translational Neuroimaging CoreP30HD071593 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WALKLEY, STEVEN UPSHAW · 2011 to 2015
$5.6M
Neural Cell Adhesion Genes in Synaptic SpecificityR01MH112689 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI EMMONS, SCOTT W · 2017 to 2021
$2.1M
Genetic analyses of complete circuit formation in Caenorhabditis elegansF32MH115438 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI COOK, STEVEN JAY · 2017 to 2021
$226k
NCRR NIH HHS R24 RR012596NICHD NIH HHS P30 HD071593NIH HHS OD 010943NIH HHS R24 OD010943NIMH NIH HHS F32 MH115438NIMH NIH HHS R01 MH112689
6 · The paper itself

Abstract

Animal nervous system organization is crucial for all body functions and its disruption can lead to severe cognitive and behavioural impairment

Indexed as

ConnectomeAnimalsBrainCaenorhabditis elegansGap JunctionsModels, BiologicalNeural PathwaysNeuritesNeuropilSynapses

Identifiers

PMID33627874
PMCPMC11648602
OpenAlexW3131776733

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.