ArticleNature2021
Reset of hippocampal-prefrontal circuitry facilitates learning.
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed.
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Psychedelics do not always enhance cognitive flexibility: The potential role of time-varying effects on reward learning processes.Neuroscience and biobehavioral reviews · 2026Review
- Intraoperative temporal interference (TI)-noninvasive brain stimulation prevents postoperative delirium in mice.Fundamental research · 2026Article
- Subcellular Localization of Dopamine D1 and D2 Receptors in the Mouse Hippocampus.The Journal of comparative neurology · 2026Article
- Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.Nature neuroscience · 2026Article
- Flexible goal learning involves coordinated population activity in dCA1 and medial orbitofrontal cortex.PLoS biology · 2026Article
- Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.Nature communications · 2026Article
- Spatial amyloid-informed multimodal brain age as an early marker of Alzheimer's-related vulnerability and risk stratification.The journal of prevention of Alzheimer's disease · 2026Article
- TARGETING INSULO-FRONTAL PATHWAY TO REDUCE STRESS-EVOKED COGNITIVE RIGIDITY.bioRxiv : the preprint server for biology · 2026Article
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- Prior novelty invigorates future mesolimbic target detection.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Emotional shaping of spatial encoding along the dorsal ventral axis of the hippocampus.Frontiers in systems neuroscience · 2026Review
- Mapping memory at scale: systems-level insights with translational and transdiagnostic relevance to fear-related disorders.Frontiers in behavioral neuroscience · 2026Review
- dCA1 cells encode and update contextual place preference.Frontiers in systems neuroscience · 2026Article
- Dynamic Interplay between Prefrontal Theta and Beta Bursts Facilitates Flexible Learning.Experimental neurobiology · 2025Article
- Cognitive training shapes brain plasticity and schematic representations.Behavioral and brain functions : BBF · 2025Review
- Investigate the differences in executive functions and behavioral baseline indicators of Parkinson's disease model mice based on the five - choice serial reaction time task.Laboratory animal research · 2025Article
- Complementary roles of dorsal and ventral hippocampus in the flexible adaptation of goal-directed behavior.Science advances · 2025Article
- Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.Brain structure & function · 2025Review
- Prior Novelty Invigorates Future Mesolimbic Target Detection.bioRxiv : the preprint server for biology · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The ability to rapidly adapt to novel situations is essential for survival, and this flexibility is impaired in many neuropsychiatric disorders
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.