ArticleBritish dental journal2021
The impact of oral health status on COVID-19 severity, recovery period and C-reactive protein values.
Article in British dental journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- The impact of periodontal disease on the clinical outcomes of COVID-19: A systematic review and meta-analysis.BMC oral health · 2023Pooled it
- Oral mucosa lesions in confirmed and non-vaccinated cases for COVID-19: A systematic review.Journal of stomatology, oral and maxillofacial surgery · 2022Pooled it
- Oral Health Implications of SARS-CoV-2/COVID-19: A Systematic Review.Oral health & preventive dentistry · 2022Pooled it
- Pooled it
- USE OF MOUTHWASH AND DENTIFRICE CONTAINING AN ANTIMICROBIAL PHTHALOCYANINE DERIVATIVE FOR THE REDUCTION OF CLINICAL SYMPTOMS OF COVID-19: A RANDOMIZED TRIPLE-BLIND CLINICAL TRIAL.The journal of evidence-based dental practice · 2022Trial
- Association between dental plaque index and COVID-19 severity: a cross-sectional study in a conflict-affected humanitarian setting.BMC oral health · 2026Article
- The ROOT-CTRCD study: exploring the relationship of oral health to cancer therapy-related cardiac dysfunction in HER2-positive breast cancer patients.Cardio-oncology (London, England) · 2026Article
- Oral and maxillofacial manifestations of COVID-19.GMS hygiene and infection control · 2026Review
- Do Diet, Oral Hygiene, and Sleep Habits Correlate with Severe COVID-19?International journal of preventive medicine · 2026Article
- Oral hygiene influence on the incidence and severity of oral manifestations in Coronavirus Disease 2019.BMC oral health · 2025Article
- Oral SARS-CoV-2 Infection and Risk for Long Covid.Reviews in medical virology · 2025Review
- Interdisciplinary research on periodontitis and depression: a bibliometric analysis of research trends, hotspots and future directions.Frontiers in oral health · 2025Article
- Oral manifestations of COVID-19 vaccinated individuals, post-infection, and different variants: a Brazilian population study.Brazilian oral research · 2025Article
- COVID-19 Severity in Patients With Apical Periodontitis: A Case Control Study.International dental journal · 2024Article
- Can toothbrushing reduce the intraoral viral load of SARS-CoV-2? A pilot study with a dentifrice containing an antimicrobial phthalocyanine derivative.GMS hygiene and infection control · 2024Article
- Hand and Oral Hygiene Practices of South Korean Adolescents Before and During the COVID-19 Pandemic.JAMA network open · 2023Article
- Article
- Article
- Bibliometric research on analysis of links between periodontitis and cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Article
- Epidemiological pattern of COVID-19 and its association with periodontal health in an urban Indian cohort.Frontiers in public health · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives The oral cavity is a potential reservoir for respiratory pathogens which can predispose patients to bacterial super-infection. Several trials have correlated poor oral hygiene with hyper-inflammation. Similarly, COVID-19 severity has been linked to hyper-inflammatory responses. Hence, in this study, we assumed that increased COVID-19 severity may be linked to poor oral health status. This was achieved through assessing oral health status, severity of COVID-19 symptoms, C-reactive protein (CRP) levels and duration of recovery.Methods Cross-sectional study based on a questionnaire; 308 Egyptian patients with confirmed positive polymerase chain reaction (PCR) tests were included in the study after exclusion criteria. The questionnaire was designed with two sections: the first section for oral health evaluation and the second section for COVID-19 severity evaluation. Assessment of the effect of oral health on COVID-19 severity was performed using an oral health score. The effect of oral health on CRP and recovery period were evaluated as secondary endpoints. Data of CRP levels and COVID-19 PCR tests were collected via the questionnaire and confirmed by reviewing medical records.Results The correlation between oral health and COVID-19 severity showed a significant inverse correlation (p <0.001, r = -0.512). Moreover, the correlation between oral health with recovery period and CRP values also revealed a significant inverse correlation (p <0.001, -0.449 and p <0.001, -0.190, respectively), showing that poor oral health was correlated to increased values of CRP and delayed recovery period.Conclusions Our study provided some evidence that oral health could have a potential impact on the severity of COVID-19. However, the correlation is limited by the study design. A more substantial research project is required to address this relation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.