ArticleScientific reports2021
Physical characterization of biphasic bioceramic materials with different granulation sizes and their influence on bone repair and inflammation in rat calvaria.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Optical Coherence Tomography, Stereomicroscopic, and Histological Aspects of Bone Regeneration on Rat Calvaria in the Presence of Bovine Xenograft or Titanium-Reinforced Hydroxyapatite.Journal of functional biomaterials · 2026Article
- Evaluation of enamel matrix derivative used alone or added to collagen membrane for tissue repair: in vivo animal study using a rat dorsal wound model.International journal of implant dentistry · 2025Article
- Bone Regeneration in Defects Created on Rat Calvaria Grafted with Porcine Xenograft and Synthetic Hydroxyapatite Reinforced with Titanium Particles-A Microscopic and Histological Study.Journal of functional biomaterials · 2025Article
- Article
- Development of Bioinspired Biphasic Calcium Phosphate Inks for Manufacturing Bone Scaffolds by Robocasting.3D printing and additive manufacturing · 2024Article
- Influence of physicochemical characteristics of calcium phosphate-based biomaterials in cranio-maxillofacial bone regeneration. A systematic literature review and meta-analysis of preclinical models.Materials today. Bio · 2024Article
- Article
- Article
- Evaluation of a Granular Bone Substitute for Bone Regeneration Using an Optimized In Vivo Alveolar Cleft Model.Bioengineering (Basel, Switzerland) · 2023Article
- Effect of platelet-rich fibrin (PRF) membranes on the healing of infected skin wounds.Archives of dermatological research · 2023Article
- Polysaccharides-Calcium Phosphates Composite Beads as Bone Substitutes for Fractures Repair and Regeneration.Polymers · 2023Article
- Biosynthesised Silver Nanoparticles Loading onto Biphasic Calcium Phosphate for Antibacterial and Bone Tissue Engineering Applications.Antibiotics (Basel, Switzerland) · 2022Article
- Radiographic and Histomorphometric Evaluation of Sinus Floor Augmentation Using Biomimetic Octacalcium Phosphate Alloplasts: A Prospective Pilot Study.Materials (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biphasic calcium phosphate bioceramics (BCP) consist of a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (β-TCP) within the same particle. Due to their osteoconductive properties, biocompatibility and resemblance to natural bone, these materials have become a promising and suitable alternative to autologous bone grafting. First, the topography characteristics, specific surface area, and total pore volume of BCP were evaluated using scanning electron microscopy and the BET and BJH methods. Next, this study aimed to evaluate the intensity of the inflammatory process and the bone neoformation capacity of various particle sizes of BCP in the repair of critical defects in the calvaria of rats. A xenogeneic biomaterial was used in the control group. After 30, 60, and 90 days, the animals were euthanized, followed by the processing of the samples to measure the intensity of inflammatory infiltrates and the areas of bone neoformation. Our results indicate that no considerable differences were observed in the inflammatory scores in sites treated with distinct BCP grain sizes. A greater area of bone neoformation was measured in the xenogeneic group at all analysis times, with no substantial differences in bone formation between the BCP particle size in the range of 250-500 µm and 500-1000 µm.
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