Evidence map›Paper›PMID 33627624›Full record

Trial reportTranslational psychiatry2021

In-vivo imaging of targeting and modulation of depression-relevant circuitry by transcranial direct current stimulation: a randomized clinical trial.

Mayank S Jog, Elizabeth Kim, Cole Anderson, Antoni Kubicki, Rishikesh Kayathi, Kay Jann, Lirong Yan, Amber Leaver, Gerhard Hellemann, Marco Iacoboni and 3 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 4 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Mayank S JogUniversity of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2519-1192
Elizabeth KimUniversity of California, Los Angeles, CA, USA.
Cole AndersonUniversity of California, Los Angeles, CA, USA.
Antoni KubickiUniversity of California, Los Angeles, CA, USA.
Rishikesh KayathiUniversity of California, Los Angeles, CA, USA.
Kay JannUniversity of Southern California, Los Angeles, CA, USA.
Lirong YanUniversity of Southern California, Los Angeles, CA, USA.
Amber LeaverNorthwestern University, Chicago, IL, USA.
Gerhard HellemannUniversity of California, Los Angeles, CA, USA.
Marco IacoboniUniversity of California, Los Angeles, CA, USA.ORCID 0000-0002-0035-5413
Roger P WoodsUniversity of California, Los Angeles, CA, USA.
Danny J J WangUniversity of Southern California, Los Angeles, CA, USA.
Katherine L NarrUniversity of California, Los Angeles, CA, USA. knarr@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Southern California · USNorthwestern University · US

Funding

Imaging-guided tDCS therapy in major depressionR33MH110526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L · 2020 to 2022
$3.2M
Imaging-guided tDCS therapy in major depressionR61MH110526 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L, WANG, DANNY JJ · 2017 to 2018
$2.2M
A tool-box to control and enhance tDCS spatial precisionR01MH111896 · NIMH · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2016 to 2019
$2.2M
NIMH NIH HHS R01 MH111896NIMH NIH HHS R33 MH110526NIMH NIH HHS R61 MH110526
6 · The paper itself

Abstract

Recent clinical trials of transcranial direct current stimulation (tDCS) in depression have shown contrasting results. Consequently, we used in-vivo neuroimaging to confirm targeting and modulation of depression-relevant neural circuitry by tDCS. Depressed participants (N = 66, Baseline Hamilton Depression Rating Scale (HDRS) 17-item scores ≥14 and <24) were randomized into Active/Sham and High-definition (HD)/Conventional (Conv) tDCS groups using a double-blind, parallel design, and received tDCS individually targeted at the left dorsolateral prefrontal cortex (DLPFC). In accordance with Ampere's Law, tDCS currents were hypothesized to induce magnetic fields at the stimulation-target, measured in real-time using dual-echo echo-planar-imaging (DE-EPI) MRI. Additionally, the tDCS treatment trial (consisting of 12 daily 20-min sessions) was hypothesized to induce cerebral blood flow (CBF) changes post-treatment at the DLPFC target and in the reciprocally connected anterior cingulate cortex (ACC), measured using pseudo-continuous arterial spin labeling (pCASL) MRI. Significant tDCS current-induced magnetic fields were observed at the left DLPFC target for both active stimulation montages (Brodmann's area (BA) 46: p

Indexed as

Transcranial Direct Current StimulationDepressionDouble-Blind MethodHumansMagnetic Resonance ImagingPrefrontal Cortex

Identifiers

PMID33627624
PMCPMC7904813
OpenAlexW3132060153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.