Evidence map›Paper›PMID 33627508›Full record

ArticlemSphere2021

Outer Membrane Structural Defects in Salmonella enterica Serovar Typhimurium Affect Neutrophil Chemokinesis but Not Chemotaxis.

Eric J Leaman, Alvin Aung, Alexie J Jacques, Bahareh Behkam

Abstract read
In one paragraph

Article in mSphere, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eric J LeamanDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia, USA.ORCID 0000-0002-0241-6400
Alvin AungDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia, USA.
Alexie J JacquesVirginia Western Community College, Roanoke, Virginia, USA.
Bahareh BehkamDepartment of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia, USA behkam@vt.edu.ORCID 0000-0002-2174-2914

Funding

National Science Foundation CBET-1454226
6 · The paper itself

Abstract

Neutrophils, the first line of defense against pathogens, are critical in the host response to acute and chronic infections. In Gram-negative pathogens, the bacterial outer membrane (OM) is a key mediator of pathogen detection; nonetheless, the effects of variations in its molecular structure on the neutrophil migratory response to bacteria remain largely unknown. Here, we developed a quantitative microfluidic assay that precludes physical contact between bacteria and neutrophils while maintaining chemical communication, thus allowing investigation of both transient and steady-state responses of neutrophils to a library of

Indexed as

ChemotaxisNeutrophil InfiltrationBacterial Outer MembraneHost-Pathogen InteractionsMicrofluidic Analytical TechniquesNeutrophilsSalmonella typhimuriumSerogroupVirulencechemokinesischemotaxishost-pathogen interactionsmicrofluidic assayneutrophilsSalmonella

Identifiers

PMID33627508
PMCPMC8544890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.