ArticleNeurology2021
Association of Memory Impairment With Concomitant Tau Pathology in Patients With Cerebral Amyloid Angiopathy.
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Article in Neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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25citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 10% of its field
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Cerebral amyloid angiopathy and amyloid load distribution detected on amyloid-positron emission tomography: A systematic review and meta-analysis.European stroke journal · 2026Pooled it
- Cognitive and psychological characteristics in patients with Cerebral Amyloid Angiopathy: a literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.Neurology · 2026Article
- Long-Term Blood Pressure Variability in Cerebral Amyloid Angiopathy is Associated with Ischemic Brain Injury and Cognitive Decline.Journal of the American Heart Association · 2026Observational
- Extent of Tau and Its Cognitive Implications in Patients With Cerebral Amyloid Angiopathy Without Cognitive Impairment.Neurology · 2026Article
- Vascular β-amyloid potentially colocalises with phosphorylated tau in cerebral amyloid angiopathy.Stroke and vascular neurology · 2026Article
- Imaging and fluid biomarkers for prognostic stratification in cerebral amyloid angiopathy.Journal of neurology · 2026Review
- Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons.Annals of medicine · 2025Review
- Cerebral amyloid angiopathy and amyloid load distribution detected on amyloid-positron emission tomography: A systematic review and meta-analysis.European stroke journal · 2025Article
- Dual-Phase C-11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy.Annals of clinical and translational neurology · 2025Article
- Neuropsychological Aspects of Sporadic Cerebral Amyloid Angiopathy: A Case Series and Narrative Review.Current Alzheimer research · 2025Review
- Differentiating Cerebral Amyloid Angiopathy From Alzheimer's Disease Using Dual Amyloid and Tau Positron Emission Tomography.Journal of stroke · 2025Article
- Cognitive Impairment in Cerebral Amyloid Angiopathy: A Single-Center Prospective Cohort Study.Journal of clinical medicine · 2024Article
- The relation of a cerebrospinal fluid profile associated with Alzheimer's disease with cognitive function and neuropsychiatric symptoms in sporadic cerebral amyloid angiopathy.Alzheimer's research & therapy · 2024Article
- Cerebral tau pathology in cerebral amyloid angiopathy.Brain communications · 2024Article
- Fluid biomarkers in cerebral amyloid angiopathy.Frontiers in neuroscience · 2024Review
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Domain-specific neuropsychological investigation of CAA with and without intracerebral haemorrhage.Journal of neurology · 2023Article
- Histopathological Correlates of Lobar Microbleeds in False-Positive Cerebral Amyloid Angiopathy Cases.Annals of neurology · 2023Article
- Apathy in Patients With Cerebral Amyloid Angiopathy: A Multimodal Neuroimaging Study.Neurology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Dorothee SchoemakerFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston. dschoemakermarcotte@mgh.harvard.edu.
Andreas CharidimouFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston.ORCID 0000-0001-5891-337X
Maria Clara Zanon ZotinFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston.
Nicolas RaposoFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston.ORCID 0000-0002-9152-4445
Keith A JohnsonFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston.
Justin S SanchezFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston.ORCID 0000-0003-4421-3078
Steven M GreenbergFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston.
Anand ViswanathanFrom the Departments of Psychiatry (D.S.), Neurology (A.C., M.C.Z.Z., K.A.J., J.S.S., S.M.G., A.V.), and Radiology (K.A.J., J.S.S.), Massachusetts General Hospital, Harvard Medical School, Boston; and Department of Neurology (N.R.), Hôpital Pierre-Paul Riquet, Centre Hospitalier Universitaire de Toulouse (University Hospital Centre), France. M.C.Z.Z. is currently at the Department of Medical Imaging, Hematology and Clinical Oncology, Ribeirao Preto Medical School, University of Sao Paulo, Brazil; N.R. is at Toulouse Neuroimaging Center, Université de Toulouse, INSERM, UPS, France; and K.A.J. is at the Department of Neurology, Brigham and Women's Hospital, Boston.
Brigham and Women's Hospital · US
Funding
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0MTHE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HYMAN, BRADLEY T. · 1985 to 2018
$42.1MVascular Pathology in Early and Asymptomatic Cerebral Amyloid AngiopathyR01AG047975 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VISWANATHAN, ANAND · 2014 to 2025
$7.5MValidation of Small-Vessel Disease Neuroimaging Biomarkers in Cerebral Amyloid Angiopathy-Related Cognitive DeclineR01NS104130 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI VISWANATHAN, ANAND · 2018 to 2022
$3.4MNCATS NIH HHS UL1 TR002541NIA NIH HHS P50 AG005134NIA NIH HHS R01 AG047975NINDS NIH HHS R01 NS104130
Abstract
objectiveRelying on tau-PET imaging, this cross-sectional study explored whether memory impairment is linked to the presence of concomitant tau pathology in individuals with cerebral amyloid angiopathy (CAA).
methodsForty-six patients with probable CAA underwent a neuropsychological examination and an MRI for quantification of structural markers of cerebral small vessel disease. A subset of these participants also completed a [
resultsPatients with probable CAA with an amnestic presentation displayed a globally more severe profile of cognitive impairment, smaller hippocampal volume (
conclusionsThese results suggest that the presence of objective memory impairment in patients with probable CAA could serve as a marker for underlying tau pathology. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that tau-PET retention is related to the presence of objective memory impairment in patients with CAA.
Indexed as
AgedCerebral Amyloid AngiopathyCross-Sectional StudiesFemaleHumansMaleMemory DisordersNeuroimagingPositron-Emission Tomographytau ProteinsMAPT protein, humantau Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.