ArticleScience translational medicine2021
Radiotherapy and immunotherapy converge on elimination of tumor-promoting erythroid progenitor cells through adaptive immunity.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 89 citations in OpenAlex.
- Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2023Trial
- Immune regulation by erythroid cells: how erythroid progenitor cells and mature red blood cells shape immunity.Nature reviews. Immunology · 2026Review
- Pregnancy promotes tumor metastasis through adenosine-induced immunosuppressive neutrophils in pre-metastatic microenvironment.Nature communications · 2026Article
- Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome-Targeted PD-L1 Degradation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- NK-cell-derived exosomes exert antitumor potency via miR-140/XYLT1/HSPG2 axis.Cellular & molecular biology letters · 2026Article
- Targeting erythroid progenitor cell metabolism to enhance cancer immunotherapy.NPJ precision oncology · 2026Review
- Epigenetic Reprogramming of Erythroid Progenitor Cells: Insights for Enhancing Cancer Immunotherapy.International journal of biological sciences · 2026Review
- Leukemia-expanded splenic CD81+ erythroblasts potentiate disease progression in mice by reshaping leukemic cell metabolism.The Journal of clinical investigation · 2025Article
- Turning cold tumors into hot tumors to ignite immunotherapy.Molecular cancer · 2025Review
- Targeting anemia-induced CD71Infection and immunity · 2025Article
- Low-dose radiotherapy enhances the efficacy of PD-L1 blockade and induces the abscopal effect.Journal for immunotherapy of cancer · 2025Article
- A γ-ray responsive hydrogel "blasting fuse" for prevention of postoperative breast cancer recurrence and metastasis via radio-immunotherapy.Materials today. Bio · 2025Article
- Advances in cancer immunotherapy: historical perspectives, current developments, and future directions.Molecular cancer · 2025Review
- Article
- Erythroid progenitor cell-mediated spleen-tumor interaction deteriorates cancer immunity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Targeting the Dendritic Cell-Secreted Immunoregulatory Cytokine CCL22 Alleviates Radioresistance.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Article
- Programmable melanoma-targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies.Nature communications · 2024Article
- Immunoregulation role of the erythroid cells.Frontiers in immunology · 2024Review
- Expression and prognosis of ADAMTS18 in different tumors.Frontiers in oncology · 2024Review
- Erythroid Cells as Full Participants in the Tumor Microenvironment.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 6 institutions in 2 countries.
Yuzhu HouDepartment of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, ShaanXi 710061, China. rrw@radonc.uchicago.edu houyz1980@126.com yang-xin.fu@utsouthwestern.edu.ORCID 0000-0001-8274-027X
Hua L LiangLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.ORCID 0000-0001-5512-8595
Xinshuang YuDepartment of Oncology, First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, China.ORCID 0000-0001-9095-3435
Zhida LiuDepartment of Pathology, University of Texas Southwest Medical Center, Dallas, TX 75235, USA.ORCID 0000-0002-3980-8440
Xuezhi CaoDepartment of Pathology, University of Texas Southwest Medical Center, Dallas, TX 75235, USA.ORCID 0000-0002-3602-4560
Enyu RaoCancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China.
Xiaona HuangLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.
Liangliang WangLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.ORCID 0000-0001-8340-5190
Lei LiLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.
Jason BugnoCommittee on Clinical Pharmacology and Pharmacogenomics, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-3046-8072
Yanbin FuLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.
Steven J ChmuraLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.ORCID 0000-0001-8851-7108
Wenjun WuFox Chase Cancer Center, Philadelphia, PA 19111, USA.
Sean Z LuoWhitney Young High School, Chicago, IL 60607, USA.
Wenxin ZhengLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.
Ainhoa ArinaLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.ORCID 0000-0002-0585-7148
Jessica JutzyLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.ORCID 0000-0001-9699-7957
Anne R McCallRadiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-6029-3915
Everett E VokesDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8645-8068
Sean P PitrodaLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA.
Yang-Xin FuDepartment of Pathology, University of Texas Southwest Medical Center, Dallas, TX 75235, USA. rrw@radonc.uchicago.edu houyz1980@126.com yang-xin.fu@utsouthwestern.edu.ORCID 0000-0002-4809-825X
Ralph R WeichselbaumLudwig Center for Metastasis Research, Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637 USA. rrw@radonc.uchicago.edu houyz1980@126.com yang-xin.fu@utsouthwestern.edu.ORCID 0000-0002-5643-8939
University of Chicago · USFox Chase Cancer Center · USThe University of Texas Southwestern Medical Center · USShandong Provincial QianFoShan Hospital · CNWhitney Museum of American Art · USXuzhou Medical College · CN
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1MCLINICAL THERAPEUTICST32GM007019 · NIGMS · UNIVERSITY OF CHICAGO · PI Peter Hugh O'Donnell, MARK J RATAIN · 1985 to 2026
$8.7MSynergy of Radiation and Immunotherapy: New ApproachesR01CA134563 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MALTER, JAMES S · 2010 to 2019
$3.4MEnhancing the abscopal effect in cancer treatment by immune modulationR21CA195075 · NCI · UNIVERSITY OF CHICAGO · PI WEICHSELBAUM, RALPH R · 2016 to 2017
$378kNCI NIH HHS P30 CA014599NCI NIH HHS R01 CA134563NCI NIH HHS R21 CA195075NIGMS NIH HHS T32 GM007019
Abstract
Tumor-induced CD45
Indexed as
Erythroid Precursor CellsNeoplasmsAdaptive ImmunityAnimalsHumansImmunotherapyMiceNerve Tissue ProteinsNerve Tissue Proteins
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.