Evidence map›Paper›PMID 33627403›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Mitochondrial hydrogen sulfide supplementation improves health in the

Rebecca A Ellwood, Jennifer E Hewitt, Roberta Torregrossa, Ashleigh M Philp, Justin P Hardee, Samantha Hughes, David van de Klashorst, Nima Gharahdaghi, Taslim Anupom, Luke Slade and 10 more

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. HHandbook of experimental pharmacology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treatedProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Review
  12. Increased mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Acute, Sublethal, and Developmental Toxicity of Kratom (International journal of environmental research and public health · 2022
    Article
  18. Article
  19. International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 5 countries.

Rebecca A EllwoodMedical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby DE22 3DT, United Kingdom.ORCID 0000-0002-0412-7530
Jennifer E HewittDepartment of Chemical Engineering, Texas Tech University, Lubbock, TX 79409.ORCID 0000-0002-8798-1811
Roberta TorregrossaUniversity of Exeter Medical School, University of Exeter, EX1 2LU Exeter, United Kingdom.ORCID 0000-0002-1809-7029
Ashleigh M PhilpMitochondrial Metabolism and Ageing, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.ORCID 0000-0002-7783-0278
Justin P HardeeCentre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0001-6469-9592
Samantha HughesHAN BioCentre, HAN University of Applied Sciences, Nijmegen 6525EM, The Netherlands.ORCID 0000-0001-8447-2563
David van de KlashorstHAN BioCentre, HAN University of Applied Sciences, Nijmegen 6525EM, The Netherlands.
Nima GharahdaghiMedical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby DE22 3DT, United Kingdom.ORCID 0000-0002-4650-244X
Taslim AnupomDepartment of Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409.ORCID 0000-0001-8944-9004
Luke SladeUniversity of Exeter Medical School, University of Exeter, EX1 2LU Exeter, United Kingdom.ORCID 0000-0001-7660-7392
Colleen S DeaneSport and Health Sciences, University of Exeter, EX1 2LU Exeter, United Kingdom.ORCID 0000-0002-2281-6479
Michael CookeMedical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby DE22 3DT, United Kingdom.ORCID 0000-0003-2081-3466
Timothy EtheridgeSport and Health Sciences, University of Exeter, EX1 2LU Exeter, United Kingdom.ORCID 0000-0002-3588-8711
Mathew PiaseckiMedical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby DE22 3DT, United Kingdom.ORCID 0000-0002-7804-4631
Adam AntebiMolecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.ORCID 0000-0002-7241-3029
Gordon S LynchCentre for Muscle Research, Department of Anatomy and Physiology, The University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0001-9220-9810
Andrew PhilpMitochondrial Metabolism and Ageing, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.ORCID 0000-0003-3860-4136
Siva A VanapalliDepartment of Chemical Engineering, Texas Tech University, Lubbock, TX 79409.ORCID 0000-0001-6036-1949
Matthew WhitemanUniversity of Exeter Medical School, University of Exeter, EX1 2LU Exeter, United Kingdom; M.Whiteman@exeter.ac.uk szewczyk@ohio.edu.ORCID 0000-0002-6583-6779
Nathaniel J SzewczykMedical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby DE22 3DT, United Kingdom; M.Whiteman@exeter.ac.uk szewczyk@ohio.edu.ORCID 0000-0003-4425-9746
University of Exeter · GBUniversity of Nottingham · GBTexas Tech University · USGarvan Institute of Medical Research · AUHAN University of Applied Sciences · NLThe University of Melbourne · AUUniversity of Cologne · DE

Funding

Biotechnology and Biological Sciences Research Council BB/N015894/1Department of HealthMedical Research Council MC_PC_16072Medical Research Council MR/K00414X/1Medical Research Council MR/P021220/1Medical Research Council MR/R502364/1Medical Research Council MR/S002626/1Medical Research Council MR/T026014/1
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder characterized by progressive muscle degeneration and weakness due to mutations in the dystrophin gene. The symptoms of DMD share similarities with those of accelerated aging. Recently, hydrogen sulfide (H

Indexed as

AnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsDNA-Binding ProteinsDystrophinForkhead Transcription FactorsGene Expression RegulationHumansHydrogen SulfideLocomotionMaleMiceMice, Inbred mdxMitochondria, MuscleMitogen-Activated Protein KinasesMorpholinesAP39 compoundCaenorhabditis elegans Proteinsdaf-16 protein, C elegansDNA-Binding Proteinsdys-1 protein, C elegansDystrophinForkhead Transcription FactorsGYY 4137Hydrogen SulfideJNK-1 protein, C elegansMitogen-Activated Protein KinasesMorpholinesOrganophosphorus CompoundsOrganothiophosphorus CompoundsPrednisoneSIR-2.1 protein, C elegansSirtuinsskn-1 protein, C elegansThionesTranscription FactorsUtrophinC. eleganshydrogen sulfidemitochondriamousemuscle

Identifiers

PMID33627403
PMCPMC7936346
OpenAlexW3132922993

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.