Evidence map›Paper›PMID 33627325›Full record

ReviewThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

The Property-Based Practical Applications and Solutions of Genetically Encoded Acetylcholine and Monoamine Sensors.

Jun Chen, Katriel E Cho, Daria Skwarzynska, Shaylyn Clancy, Nicholas J Conley, Sarah M Clinton, Xiaokun Li, Li Lin, J Julius Zhu

Abstract readReview
In one paragraph

Review in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun ChenDepartment of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University.
Katriel E ChoNeuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, Virginia 22908.ORCID 0000-0003-3596-0709
Daria SkwarzynskaNeuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, Virginia 22908.
Shaylyn ClancyTools for Modern Neurobiology Class of 2020, University of Virginia School of Medicine, Charlottesville, Virginia 22908.
Nicholas J ConleyNeuroscience Graduate Program, University of Virginia School of Medicine, Charlottesville, Virginia 22908.ORCID 0000-0001-7160-9719
Sarah M ClintonSchool of Neuroscience, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061.
Xiaokun LiPharmaceutical Sciences Graduate Program, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Li LinDepartment of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University linliwz@163.com.ORCID 0000-0003-3355-6139
J Julius ZhuDepartment of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia 22908.ORCID 0000-0002-1879-983X

Funding

Training in Cell and Molecular BiologyT32GM139787 · NIGMS · UNIVERSITY OF VIRGINIA · PI Bryce Paschal · 2021 to 2026
$2.5M
Genetically-encoded ACh sensorsR01NS104670 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2018 to 2022
$2.2M
Calcium channel and glutamate receptor signaling at synapsesR01NS091452 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2015 to 2019
$1.7M
Synaptic Depression: Focus on Cdk5 SignalingR01NS092548 · NINDS · UNIVERSITY OF VIRGINIA · PI ZHU, J. JULIUS · 2015 to 2019
$1.7M
NIGMS NIH HHS T32 GM139787NINDS NIH HHS R01 NS091452NINDS NIH HHS R01 NS092548NINDS NIH HHS R01 NS104670
6 · The paper itself

Abstract

Neuromodulatory communication among various neurons and non-neuronal cells mediates myriad physiological and pathologic processes, yet defining regulatory and functional features of neuromodulatory transmission remains challenging because of limitations of available monitoring tools. Recently developed genetically encoded neuromodulatory transmitter sensors, when combined with superresolution and/or deconvolution microscopy, allow the first visualization of neuromodulatory transmission with nanoscale or microscale spatiotemporal resolution.

Indexed as

AcetylcholineAnimalsBiogenic MonoaminesCell CommunicationHumansNeuronsNeurotransmitter AgentsSynapsesSynaptic TransmissionAcetylcholineBiogenic MonoaminesNeurotransmitter Agentsacetylcholinedopamineneuromodulationnorepinephrineserotoninsuperresolution and deconvolution microscopysynaptic transmission

Identifiers

PMID33627325
PMCPMC7984589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.