Evidence map›Paper›PMID 33627317›Full record

ArticleBMJ open diabetes research & care2021

Serum calcification propensity is associated with HbA1c in type 2 diabetes mellitus.

Rik Mencke, Amarens van der Vaart, Andreas Pasch, Geert Harms, Femke Waanders, Henk J G Bilo, Harry van Goor, Jan-Luuk Hillebrands, Peter R van Dijk

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01570140 (Large Scale Demonstrator, Webportal Diabetes), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01570140 completednot on this map

Large Scale Demonstrator, Webportal Diabetes

TypeobservationalSponsorHenk Bilo, MDRan2012 to 2015Enrolled350ConditionsDiabetes Mellitus Type 2ArmsWeb portal
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Calciprotein crystallization time (TCardiovascular diabetology · 2025
    Article
  4. Observational
  5. Article
  6. Article
  7. Article
  8. Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in Type 2 Diabetes.Medical science monitor : international medical journal of experimental and clinical research · 2024
    Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Phosphate and fibroblast growth factor 23 in diabetes.Clinical science (London, England : 1979) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rik MenckeDepartment of Pathology and Medical Biology - Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Amarens van der VaartDepartment of Pathology and Medical Biology - Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Andreas PaschCalciscon AG, Nidau, Switzerland.
Geert HarmsDepartment of Pathology and Medical Biology - Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Femke WaandersDepartment of Internal Medicine, Isala, Zwolle, The Netherlands.
Henk J G BiloDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Harry van GoorDepartment of Pathology and Medical Biology - Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Jan-Luuk HillebrandsDepartment of Pathology and Medical Biology - Division of Pathology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Peter R van DijkDepartment of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands p.r.van.dijk@umcg.nl.ORCID 0000-0002-9702-6551
University Medical Center Groningen · NLIsala · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSerum calcification propensity is emerging as an independent predictor for cardiovascular outcomes in high-risk populations. Calcification propensity can be monitored by the maturation time of calciprotein particles in serum (T RESEARCH DESIGN AND

methodsUsing nephelometry, serum T

resultsSerum T

conclusionsSerum calcification propensity is independently associated with glycemic control, suggesting that a lower HbA1c may be associated with better cardiovascular outcomes. Retrospective analysis could not establish an association between a history of macrovascular events and T TRIAL REGISTRATION NUMBER: NCT01570140.

Indexed as

CalcinosisDiabetes Mellitus, Type 2AgedFemaleGlycated HemoglobinHumansMaleProspective StudiesRetrospective StudiesGlycated Hemoglobincalciumcardiovascular systemdiabetes mellitushyperglycaemiatype 2

Identifiers

PMID33627317
PMCPMC7908279
OpenAlexW3129631992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.