ArticleParasites & vectors2021
Whole blood and blood components from vertebrates differentially affect egg formation in three species of anautogenous mosquitoes.
Article in Parasites & vectors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- The food of life: which nectar do mosquitoes feed on?-An evidence-based meta-analysis.Environmental entomology · 2025Pooled it
- Isoleucine absence from adult human hemoglobin is mirrored in mosquito proteomes and limits malaria parasite growth.bioRxiv : the preprint server for biology · 2026Article
- Molecular xenomonitoring for identifying Plasmodium parasites and blood meal sources of mosquitoes in malaria endemic villages adjacent to the southern Rift Valley Lakes, South Ethiopia.Scientific reports · 2026Article
- Flower- and Water-Dwelling Yeasts Influence Nectar-Seeking and Oviposition Behavior in the Asian Tiger Mosquito with Distinct Volatile Organic Compound Profiles.Journal of chemical ecology · 2026Article
- Establishing and sustaining mosquito colonies: insights into morphology, bionomics, and advances in the rearing ofFrontiers in insect science · 2026Review
- Temporal changes in amino acid profiles coordinate mosquito physiology and egg maturation in Aedes aegypti.BMC biology · 2025Article
- Insulin-like peptides activate egg formation in the Asian malaria mosquito Anopheles stephensi.Parasites & vectors · 2025Article
- Protocol for laboratory rearing and infection tracking of Rhodnius prolixus using 3D-printable designs.STAR protocols · 2025Article
- Do the microbiota of larval breeding site and the blood meal influence the composition and diversity of bacterial communities in the midgut of Mansonia humeralis (Diptera: Culicidae) from the western Amazon?Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
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- The artificial meal SkitoSnack does not support reproduction in Culex pipiens (Diptera: Culicidae) mosquitoes.Journal of insect science (Online) · 2025Article
- Article
- Anopheles gambiae phagocytic hemocytes promote Plasmodium falciparum infection by regulating midgut epithelial integrity.Nature communications · 2025Article
- Fertility decline in Aedes aegypti (Diptera: Culicidae) mosquitoes is associated with reduced maternal transcript deposition and does not depend on female age.Journal of medical entomology · 2024Article
- Reciprocal interactions between neuropeptide F and RYamide regulate host attraction in the mosquitoProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Article
- Insulin-like peptides and ovary ecdysteroidogenic hormone differentially stimulate physiological processes regulating egg formation in the mosquito Aedes aegypti.Insect biochemistry and molecular biology · 2023Article
- The mosquito Aedes aegypti requires a gut microbiota for normal fecundity, longevity and vector competence.Communications biology · 2023Article
- Gene coexpression network during ontogeny in the yellow fever mosquito, Aedes aegypti.BMC genomics · 2023Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMost female mosquitoes are anautogenous and must blood feed on a vertebrate host to produce eggs. Prior studies show that the number of eggs females lay per clutch correlates with the volume of blood ingested and that protein is the most important macronutrient for egg formation. In contrast, how whole blood, blood fractions and specific blood proteins from different vertebrates affect egg formation is less clear. Since egg formation is best understood in Aedes aegypti, we examined how blood and blood components from different vertebrates affect this species and two others: the malaria vector Anopheles gambiae and arbovirus vector Culex quinquefasciatus.
methodsAdult female mosquitoes were fed blood, blood fractions and purified major blood proteins from different vertebrate hosts. Markers of reproductive response including ovary ecdysteroidogenesis, yolk deposition into oocytes and number of mature eggs produced were measured.
resultsAe. aegypti, An. gambiae and C. quinquefasciatus responded differently to meals of whole blood, plasma or blood cells from human, rat, chicken and turkey hosts. We observed more similarities between the anthropophiles Ae. aegypti and An. gambiae than the ornithophile C. quinquefasciatus. Focusing on Ae. aegypti, the major plasma-derived proteins (serum albumin, fibrinogen and globulins) differentially stimulated egg formation as a function of vertebrate host source. The major blood cell protein, hemoglobin, stimulated yolk deposition when from pigs but not humans, cows or sheep. Serum albumins from different vertebrates also variably affected egg formation. Bovine serum albumin (BSA) stimulated ovary ecdysteroidogenesis, but more weakly induced digestive enzyme activities than whole blood. In contrast, BSA-derived peptides and free amino acids had no stimulatory effects on ecdysteroidogenesis or yolk deposition into oocytes.
conclusionsWhole blood, blood fractions and specific blood proteins supported egg formation in three species of anautogenous mosquitoes but specific responses varied with the vertebrate source of the blood components tested.
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