Observational studyRespiratory research2021
Impulse oscillometry for detection of small airway dysfunction in subjects with chronic respiratory symptoms and preserved pulmonary function.
Observational study in Respiratory research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07046442 (Effect of Pulmonary Rehabilitation and Physical Activity on the Symptoms of Long COVID. A Pilot Study), which is not on this map. Cited by 55 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Pulmonary Rehabilitation and Physical Activity on the Symptoms of Long COVID. A Pilot Study
Who cites it
55 citing papers in PubMed.
- Effect of periodontal therapy on lung function: a twelve-month follow-up intervention study.Respiratory research · 2025Trial
- Exacerbation Burden and Peripheral Airway Dysfunction as Determinants of Quality of Life in Bronchiectasis: Insights from Impulse Oscillometry.Medicina (Kaunas, Lithuania) · 2026Observational
- Airborne Ultrasound Surface Motion Camera: Application to Transfer Admittance Chest Imaging.Annals of biomedical engineering · 2026Article
- Current use and future potential of oscillometry in UK lung function testing: a national survey.BMJ open respiratory research · 2026Article
- Article
- Review
- Automated identification of chronic obstructive pulmonary disease and asthma using impulse oscillometry combined with quantitative computed tomography parameters and radiomics features.Journal of thoracic disease · 2026Article
- Role of Airwave Oscillometry in Patients with Combined Fibrosis-Emphysema Syndrome (CPFE) with Preserved FEV1/FVC Ratio.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Respiratory mechanics: modelling, measurement and clinical applications-a review.Biomedical engineering online · 2026Review
- Impulse oscillometry and traditional pulmonary function testing: correlation, advances and clinical implications.BMJ open respiratory research · 2026Review
- Impulse oscillometry values calibrated against spirometric obstruction in children with suspected asthma.Frontiers in pediatrics · 2026Article
- Respiratory symptoms and pulmonary physiologic outcomes among post-9/11 veterans with blast exposure.Frontiers in public health · 2026Article
- Association between impulse oscillometry Z-scores and asthma control and exacerbation risk in a tertiary severe asthma clinic.Frontiers in allergy · 2026Article
- Metabolomic Clusters and Their Association with Small Airway Disease in Asthma.Journal of asthma and allergy · 2026Article
- Impulse oscillometry-defined airway abnormalities as a treatable trait for mild-to-moderate COPD: a prospective cohort study with 3-year follow-up.ERJ open research · 2025Article
- Impulse oscillometry for the detection of small airway dysfunction in patients with chronic respiratory symptoms, preserved ratio impaired spirometry and COPD.BMC pulmonary medicine · 2025Article
- Effort-independent respiratory monitoring in Duchenne muscular dystrophy: clinical value of impulse oscillometry.European journal of pediatrics · 2025Article
- Glycopyrrolate/formoterol fumarate MDI in mild-to-moderate chronic obstructive pulmonary disease (PIONEER): a protocol for a randomised, double-blind, placebo-controlled trial.BMJ open respiratory research · 2025Article
- Early benefit of mepolizumab on small airways in severe asthma: insights from the IMPOSE study.ERJ open research · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundSubjects with chronic respiratory symptoms and preserved pulmonary function (PPF) may have small airway dysfunction (SAD). As the most common means to detect SAD, spirometry needs good cooperation and its reliability is controversial. Impulse oscillometry (IOS) may complete the deficiency of spirometry and have higher sensitivity. We aimed to explore the diagnostic value of IOS to detect SAD in symptomatic subjects with PPF.
methodsThe evaluation of symptoms, spirometry and IOS results in 209 subjects with chronic respiratory symptoms and PPF were assessed. ROC curves of IOS to detect SAD were analyzed.
results209 subjects with chronic respiratory symptoms and PPF were included. Subjects who reported sputum had higher R5-R20 and Fres than those who didn't. Subjects with dyspnea had higher R5, R5-R20 and AX than those without. CAT and mMRC scores correlated better with IOS parameters than with spirometry. R5, R5-R20, AX and Fres in subjects with SAD (n = 42) significantly increased compared to those without. Cutoff values for IOS parameters to detect SAD were 0.30 kPa/L s for R5, 0.015 kPa/L s for R5-R20, 0.30 kPa/L for AX and 11.23 Hz for Fres. Fres has the largest AUC (0.665, P = 0.001) among these parameters. Compared with spirometry, prevalence of SAD was higher when measured with IOS. R5 could detect the most SAD subjects with a prevalence of 60.77% and a sensitivity of 81% (AUC = 0.659, P = 0.002).
conclusionIOS is more sensitive to detect SAD than spirometry in subjects with chronic respiratory symptoms and PPF, and it correlates better with symptoms. IOS could be an additional method for SAD detection in the early stage of diseases.
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