Evidence map›Paper›PMID 33627072›Full record

ArticleBMC infectious diseases2021

Differences in the clinical characteristics and outcomes of COVID-19 patients in the epicenter and peripheral areas of the pandemic from China: a retrospective, large-sample, comparative analysis.

Gang Wang, Feng Ming Luo, Dan Liu, Jia Sheng Liu, Ye Wang, Hong Chen, Pan Wen Tian, Tao Fan, Li Tang, He Yu and 19 more

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 11 institutions in 1 country.

Gang Wang *Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Feng Ming Luo *Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Dan Liu *Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Jia Sheng Liu *Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Ye WangDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Hong ChenDepartment of Critical Care Medicine, Public Health Clinical Center of Chengdu, Chengdu, 610061, Sichuan, China.
Pan Wen TianDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Tao FanDepartment of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Li TangDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
He YuDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Lan WangDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Mei FengDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Zhong NiDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Bo WangDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Zhi Fang SongDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Xiao Ling WuDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Hong Jun WangDepartment of Respiratory Medicine, Dazhou Central Hospital, Dazhou, 635000, Sichuan, China.
Xiang TongDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Miao XueDepartment of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China.
Xian Ying LeiDepartment of Critical Care Medicine, Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Bo LongMianyang 404 Hospital, Mianyang, 621000, Sichuan, China.
Chao JiaDepartment of Critical Care Medicine, Mianyang Central Hospital, Mianyang, 621000, Sichuan, China.
Jun XiaoDepartment of Respiratory and Critical Care Medicine, People's Hospital of Ganzi Prefecture, Ganzi, 626700, Sichuan, China.
Juan ShangDepartment of Critical Care Medicine, Nanchong Central Hospital, Nanchong, 637000, Sichuan, China.
Nian Xiong *Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, Hubei, China. nianxiong@hust.edu.cn.
Jian Fei Luo *Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China. afei099@163.com.
Zong An Liang *Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. liang.zongan@163.com.
Wei Min Li *Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. weimi003@scu.edu.cn.
Sichuan & Wuhan Collaboration Research Group, and Sichuan Treatment Expert Group for COVID-19, China
West China Hospital of Sichuan University · CNSichuan University · CNWuhan University · CNAffiliated Hospital of Southwest Medical University · CNDazhou Central Hospital · CNGanzhou People's Hospital · CNMianyang Central Hospital · CNNanchong Central Hospital · CNPublic Health Clinical Center of Chengdu · CNSichuan Mianyang 404 Hospital · CNUnion Hospital · CN

Funding

National Key Development Plan for Precision Medicine Research 2017YFC091004National Natural Science Foundation of China 81920108002Sichuan Provincial Program for Diagnostic and Treatment of Covid-19 2020YFS002 and 2020YFS005
6 · The paper itself

Abstract

backgroundThere is limited information on the difference in epidemiology, clinical characteristics and outcomes of the initial outbreak of the coronavirus disease (COVID-19) in Wuhan (the epicenter) and Sichuan (the peripheral area) in the early phase of the COVID-19 pandemic. This study was conducted to investigate the differences in the epidemiological and clinical characteristics of patients with COVID-19 between the epicenter and peripheral areas of pandemic and thereby generate information that would be potentially helpful in formulating clinical practice recommendations to tackle the COVID-19 pandemic.

methodsThe Sichuan & Wuhan Collaboration Research Group for COVID-19 established two retrospective cohorts that separately reflect the epicenter and peripheral area during the early pandemic. The epidemiology, clinical characteristics and outcomes of patients in the two groups were compared. Multivariate regression analyses were used to estimate the adjusted odds ratios (aOR) with regard to the outcomes.

resultsThe Wuhan (epicenter) cohort included 710 randomly selected patients, and the peripheral (Sichuan) cohort included 474 consecutive patients. A higher proportion of patients from the periphery had upper airway symptoms, whereas a lower proportion of patients in the epicenter had lower airway symptoms and comorbidities. Patients in the epicenter had a higher risk of death (aOR=7.64), intensive care unit (ICU) admission (aOR=1.66), delayed time from illness onset to hospital and ICU admission (aOR=6.29 and aOR=8.03, respectively), and prolonged duration of viral shedding (aOR=1.64).

conclusionsThe worse outcomes in the epicenter could be explained by the prolonged time from illness onset to hospital and ICU admission. This could potentially have been associated with elevated systemic inflammation secondary to organ dysfunction and prolonged duration of virus shedding independent of age and comorbidities. Thus, early supportive care could achieve better clinical outcomes.

Indexed as

SARS-CoV-2AdultAgedChinaComorbidityCOVID-19FemaleHumansIntensive Care UnitsMaleMiddle AgedRetrospective StudiesVirus SheddingCase fatalityComparative analysisCOVID-19EpicenterPandemicPeripheral area

Identifiers

PMID33627072
PMCPMC7903397
OpenAlexW3111014761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.