Evidence map›Paper›PMID 33626909›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Reelin Depletion Protects Against Atherosclerosis by Decreasing Vascular Adhesion of Leukocytes.

Laurent Calvier, Xunde Xian, Richard G Lee, Anastasia Sacharidou, Chieko Mineo, Philip W Shaul, Maria Z Kounnas, Shirling Tsai, Joachim Herz

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Genetic or therapeutic disruption of the Reelin/Apoer2 signaling pathway improves inflammatory arthritis outcomes.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Review
  5. ScienceBank · 2025
    Article
  6. Leukocyte-lymphatic intersections during cardiac inflammation.Journal of molecular and cellular cardiology · 2025
    Review
  7. Article
  8. Unraveling the Impact ofLife (Basel, Switzerland) · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Editorial: New Advances in Cardiorenal Syndrome.Frontiers in cardiovascular medicine · 2022
    Article
  18. Article
  19. The role of autophagy in hepatic fibrosis.American journal of translational research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Laurent CalvierDepartment of Molecular Genetics (L.C., X.X., J.H.), University of Texas (UT) Southwestern Medical Center, Dallas.
Xunde XianDepartment of Molecular Genetics (L.C., X.X., J.H.), University of Texas (UT) Southwestern Medical Center, Dallas.
Richard G LeeIonis Pharmaceuticals, Inc, San Diego, CA (R.G.L.).
Anastasia SacharidouCenter for Pulmonary and Vascular Biology, Department of Pediatrics (A.S., C.M., P.W.S.), University of Texas (UT) Southwestern Medical Center, Dallas.
Chieko MineoCenter for Pulmonary and Vascular Biology, Department of Pediatrics (A.S., C.M., P.W.S.), University of Texas (UT) Southwestern Medical Center, Dallas.
Philip W ShaulCenter for Pulmonary and Vascular Biology, Department of Pediatrics (A.S., C.M., P.W.S.), University of Texas (UT) Southwestern Medical Center, Dallas.
Maria Z KounnasReelin Therapeutics, Inc, La Jolla, CA (M.Z.K.).
Shirling TsaiDepartment of Surgery (S.T.), UT Southwestern Medical Center, Dallas, TX.
Joachim HerzDepartment of Molecular Genetics (L.C., X.X., J.H.), University of Texas (UT) Southwestern Medical Center, Dallas.
Southwestern Medical Center · USIonis Pharmaceuticals (United States) · USMinistry of Education · RORodin Therapeutics (United States) · US

Funding

TRAINING PROGRAM IN LUNG BIOLOGY AND DISEASET32HL098040 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAUL, PHILIP W, TERADA, LANCE S · 2009 to 2024
$4.6M
Metabolism of the VLDL receptor and ApoE receptor 2R37HL063762 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2010 to 2019
$4.0M
Unraveling ApoE4 Promotion of Cardiometabolic DiseaseR01HL144969 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAUL, PHILIP W · 2020 to 2023
$2.6M
Physiology and Pathophysiology of Apolipoprotein E receptor-2 splicing in Alzheimer's diseaseRF1AG053391 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2016 to 2020
$2.4M
Molecular Basis of Synaptic Suppression by ApoER01NS093382 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI HERZ, JOACHIM J · 2016 to 2020
$2.0M
Molecular Basis of Pregnancy Complications in the Antiphospholipid SyndromeR01HD094395 · NICHD · UT SOUTHWESTERN MEDICAL CENTER · PI MINEO, CHIEKO · 2018 to 2022
$1.8M
Endothelial Basis of Obesity-induced Insulin ResistanceR01DK110127 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MINEO, CHIEKO · 2016 to 2019
$1.8M
Dichotomous Role of Endothelial SR-BI in AtherosclerosisR01HL131597 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI SHAUL, PHILIP W · 2017 to 2020
$1.6M
Discovery of Novel Interventions of the Antiphospholipid SyndromeR01HL109604 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI MINEO, CHIEKO · 2011 to 2014
$1.6M
NHLBI NIH HHS R01 HL109604NHLBI NIH HHS R01 HL131597NHLBI NIH HHS R01 HL144969NHLBI NIH HHS R37 HL063762NHLBI NIH HHS T32 HL098040NIA NIH HHS RF1 AG053391NICHD NIH HHS R01 HD094395NIDDK NIH HHS R01 DK110127NINDS NIH HHS R01 NS093382
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

AnimalsAntibodies, NeutralizingAtherosclerosisCell AdhesionCell Adhesion Molecules, NeuronalCoculture TechniquesCX3C Chemokine Receptor 1Disease Models, AnimalEndothelial CellsExtracellular Matrix ProteinsFemaleGreen Fluorescent ProteinsHumansLDL-Receptor Related ProteinsLeukocyte RollingLeukocytesAntibodies, NeutralizingCell Adhesion Molecules, NeuronalCX3C Chemokine Receptor 1Cx3cr1 protein, mouseExtracellular Matrix ProteinsGreen Fluorescent ProteinsLDL-Receptor Related Proteinslow density lipoprotein receptor-related protein 8Nerve Tissue ProteinsOligonucleotides, AntisenseReceptors, LDLReelin ProteinRELN protein, humanReln protein, mouseSerine Endopeptidasesatherosclerosisendothelial cellsmonocytesphosphorylationplasma

Identifiers

PMID33626909
PMCPMC7990715
OpenAlexW3129854609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.