Evidence map›Paper›PMID 33626360›Full record

ArticleAmerican journal of ophthalmology2021

Qualitative Evaluation of the 10-2 and 24-2 Visual Field Tests for Detecting Central Visual Field Abnormalities in Glaucoma.

Adi Orbach, Ghee Soon Ang, Andrew S Camp, Derek S Welsbie, Felipe A Medeiros, Christopher A Girkin, Massimo A Fazio, Won Hyuk Oh, Robert N Weinreb, Linda M Zangwill and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Adi OrbachFrom the Centre for Eye Research Australia (A.O., G.S.A., Z.W.), Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
Ghee Soon AngFrom the Centre for Eye Research Australia (A.O., G.S.A., Z.W.), Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
Andrew S CampHamilton Glaucoma Center (A.S.C., D.S.W., W.H.O., R.N.W., L.M.Z.), Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Derek S WelsbieHamilton Glaucoma Center (A.S.C., D.S.W., W.H.O., R.N.W., L.M.Z.), Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Felipe A MedeirosDuke Eye Center and Department of Ophthalmology (F.A.M.), Duke University School of Medicine, Durham, North Carolina.
Christopher A GirkinDepartment of Ophthalmology and Visual Sciences (C.A.G., M.A.F.), University of Alabama at Birmingham, Birmingham, Alabama.
Massimo A FazioDepartment of Ophthalmology and Visual Sciences (C.A.G., M.A.F.), University of Alabama at Birmingham, Birmingham, Alabama.
Won Hyuk OhHamilton Glaucoma Center (A.S.C., D.S.W., W.H.O., R.N.W., L.M.Z.), Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Robert N WeinrebHamilton Glaucoma Center (A.S.C., D.S.W., W.H.O., R.N.W., L.M.Z.), Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Linda M ZangwillHamilton Glaucoma Center (A.S.C., D.S.W., W.H.O., R.N.W., L.M.Z.), Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, California.
Zhichao WuFrom the Centre for Eye Research Australia (A.O., G.S.A., Z.W.), Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia; Ophthalmology, Department of Surgery (Z.W.), The University of Melbourne, Melbourne, Victoria, Australia.. Electronic address: wu.z@unimelb.edu.au.
University of California San Diego · USCentre for Eye Research Australia · AUUniversity of Alabama at Birmingham · USDuke University · USThe University of Melbourne · AU

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAWRENCE C SINCICH · 1985 to 2026
$16.9M
African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Derek Stuart Welsbie · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
Diagnostic Innovations in Glaucoma Study (DIGS): Functional ImpairmentR01EY021818 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 2011 to 2015
$3.4M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
NEI NIH HHS P30 EY003039NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY021818NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS U10 EY014267
6 · The paper itself

Abstract

purposeTo examine whether glaucomatous central visual field abnormalities can be more effectively detected using a qualitative, expert evaluation of the 10-2 test compared with the topographically corresponding central 12 locations of the 24-2 test (C24-2).

designCross-sectional study.

methodsEyes with a glaucomatous optic nerve appearance or ocular hypertension (n = 523) and healthy eyes (n = 107) were included as cases and control subjects, respectively. The 10-2 and C24-2 visual field results of all eyes were graded by 4 glaucoma specialists for the probability that central visual field abnormalities were present.

resultsThe sensitivity of the 10-2 and C24-2 tests for detecting the cases at 95% specificity were not significantly different (e.g., 32.2% and 31.4%, respectively, for grader 1, P = .87; all graders P ≥ .25). At 95% specificity, the pattern standard deviation values from these tests had a similar sensitivity to the qualitative evaluation for the C24-2 test for all graders (P ≥ .083), but it had a significantly higher sensitivity than the qualitative evaluation for the 10-2 test for 3 graders (P ≤ .016).

conclusionsThe similarity in performance of the 10-2 and C24-2 test suggests that the increased sampling density of the former does not significantly improve the detection of central visual field abnormalities, even when based on expert assessment. These findings should not be taken to mean that the 10-2 test is not useful, but it underscores the need for its utility to be clearly established before incorporating it as routine glaucoma standard of care.

Indexed as

GlaucomaOptic Nerve DiseasesCross-Sectional StudiesHumansIntraocular PressureSensitivity and SpecificityVision DisordersVisual FieldsVisual Field Tests

Identifiers

PMID33626360
PMCPMC8379296
OpenAlexW3133035864

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.