Evidence map›Paper›PMID 33626169›Full record

ArticleOphthalmic surgery, lasers & imaging retina2021

Patterns and Predictors of Successful Treatment Discontinuation in Retinal Vein Occlusions With Macular Edema in the Real World.

Therlinder Lo, Daniella Lent-Schochet, Kieu-Yen Luu, Ajay E Kuriyan, Menachem Y Weiss, Aleksandra V Rachitskaya, Rishi P Singh, Karen M Wai, J Peter Campbell, Kishan Gupta and 3 more

Open access · greenAbstract read
In one paragraph

Article in Ophthalmic surgery, lasers & imaging retina, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Therlinder Lo
Daniella Lent-Schochet
Kieu-Yen Luu
Ajay E Kuriyan
Menachem Y Weiss
Aleksandra V Rachitskaya
Rishi P Singh
Karen M Wai
J Peter Campbell
Kishan Gupta
Eric Nudleman
Kevin C Chen
Glenn Yiu
University of California, Davis · USCleveland Clinic · USOregon Health & Science University · USUniversity of California, San Diego · USUniversity of Rochester · US

Funding

Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI TED S ACOTT · 1995 to 2026
$19.4M
VISUAL SCIENCE RESEARCH CTR SUPPORTP30EY001319 · NEI · UNIVERSITY OF ROCHESTER · PI William H Merigan · 1985 to 2026
$17.5M
Mentored Vision Clinician-Scientist Program at OHSUK12EY027720 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI David Huang · 2018 to 2026
$2.2M
A nanoparticle platform for targeted delivery of therapeutic agents to retinal pigment epithelial or choroidal endothelial cellsK08EY026101 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YIU, GLENN · 2016 to 2020
$1.0M
Role of PDLIM1 in Retinal Vascular Leakage and ProliferationK08EY028999 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NUDLEMAN, ERIC D · 2018 to 2020
$713k
Optogenetic Control of Oxidative Stress as a Model of Geographic AtrophyR21EY031108 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YIU, GLENN · 2019 to 2019
$312k
NEI NIH HHS K08 EY026101NEI NIH HHS K08 EY028999NEI NIH HHS K12 EY027720NEI NIH HHS P30 EY001319NEI NIH HHS P30 EY010572NEI NIH HHS R21 EY031108
6 · The paper itself

Abstract

BACKGROUND AND

objectiveTo identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings. PATIENTS AND

methodsRetrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence and (2) best-corrected visual acuity (BCVA) at 24 months.

resultsForty percent of eyes with branch RVO and 35% with central RVO (CRVO) / hemi-retinal RVO (HRVO) successfully discontinued therapy without fluid recurrence, with median time to discontinuation of 6 and 7 months, respectively. Lower 6-month central subfield thickness was associated with greater likelihood of treatment discontinuation within 24 months for eyes with CRVO/HRVO (P = .001), whereas better 6-month BCVA was associated with better 24-month BCVA for all RVO subtypes (P < .001).

conclusionEarly anatomic response at 6 months is associated with greater likelihood of stopping treatments. [Ophthalmic Surg Lasers Imaging Retina. 2021;52:84-92.].

Indexed as

Macular EdemaRetinal Vein OcclusionAngiogenesis InhibitorsFollow-Up StudiesHumansIntravitreal InjectionsRetinaRetrospective StudiesTomography, Optical CoherenceTreatment OutcomeVisual AcuityAngiogenesis Inhibitors

Identifiers

PMID33626169
PMCPMC8324064
OpenAlexW3132055898

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.