ArticlePloS one2021
Intraoperative blood loss may be associated with myocardial injury after non-cardiac surgery.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Myocardial injury in noncardiac surgery.Korean journal of anesthesiology · 2022Trial
- Incidence and outcomes of pulmonary artery injury during anatomical lung resection for lung cancer: a nationwide database study in Japan.Surgery today · 2026Article
- Machine Learning for Intraoperative Bleeding Prediction in Patients Undergoing Surgery: Scoping Review.JMIR medical informatics · 2026Article
- Myocardial Injury After Lung Cancer Surgery: Incidence, Characteristics, Risk Factors, and Prognosis: A Retrospective Cohort Study.Annals of surgical oncology · 2026Article
- A postoperative dynamic nomogram for predicting myocardial injury after noncardiac surgery in high-risk patients undergoing laparoscopic colorectal cancer resection.BMC anesthesiology · 2026Article
- Establishment of a nomogram for early risk prediction of severe trauma in primary medical institutions: A multi-center study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Risk factors and prognosis of postoperative acute myocardial infarction in elderly hip fracture patients combined with coronary heart disease.Journal of orthopaedic surgery and research · 2024Article
- Article
- Cardiac interventions on total knee arthroplasty: a national inpatient sample-based analysis.Archives of orthopaedic and trauma surgery · 2024Article
- Prediction model for myocardial injury after non-cardiac surgery using machine learning.Scientific reports · 2023Article
- Perioperative myocardial injury after elective neurosurgery: incidence, risk factors, and effects on mortality.Neurosurgical review · 2022Article
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the association between intraoperative blood loss and myocardial injury after non-cardiac surgery (MINS), which is a severe and common postoperative complication.
methodsWe compared the incidence of MINS based on significant intraoperative bleeding, defined as an absolute hemoglobin level < 7 g/dL, a relative hemoglobin level less than 50% of the preoperative measurement, or need for packed red cell transfusion. We also estimated a threshold for intraoperative hemoglobin level associated with MINS.
resultsWe stratified a total of 15,926 non-cardiac surgical patients with intraoperative hemoglobin and postoperative cardiac troponin (cTn) measurements according to the occurrence of significant intraoperative bleeding; 13,416 (84.2%) had no significant bleeding while 2,510 (15.8%) did have significant bleeding. After an adjustment with inverse probability weighting, the incidence of MINS was higher in the significant bleeding group (35.2% vs. 16.4%; odds ratio, 1.58; 95% confidence interval, 1.43-1.75; p < 0.001). The threshold of intraoperative hemoglobin associated with MINS was estimated to be 9.9 g/dL with an area under the curve of 0.643.
conclusionIntraoperative blood loss appeared to be associated with MINS. Further studies are needed to confirm these findings. CLINICAL REGISTRATION: The cohort was registered before patient enrollment at https://cris.nih.go.kr (KCT0004244).
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