Evidence map›Paper›PMID 33625843›Full record

ArticleEnvironmental science & technology2021

Censoring Trace-Level Environmental Data: Statistical Analysis Considerations to Limit Bias.

Barbara Jane George, Leslie Gains-Germain, Kristin Broms, Kelly Black, Marschall Furman, Michael D Hays, Kent W Thomas, Jane Ellen Simmons

Abstract read
In one paragraph

Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  13. Bayesian inference of chemical exposures from NHANES urine biomonitoring data.Journal of exposure science & environmental epidemiology · 2022
    Article
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  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Barbara Jane GeorgeCenter for Public Health and Environmental Assessment, Office of Research and Development, U.S. EPA, 109 T.W. Alexander Dr., MD-B105-01, Research Triangle Park, North Carolina 27711, United States.ORCID 0000-0001-6159-2888
Leslie Gains-GermainNeptune and Company, Inc., 1435 Garrison Street, Suite 201, Lakewood, Colorado 80215, United States.
Kristin BromsNeptune and Company, Inc., 1435 Garrison Street, Suite 201, Lakewood, Colorado 80215, United States.
Kelly BlackNeptune and Company, Inc., 1435 Garrison Street, Suite 201, Lakewood, Colorado 80215, United States.
Marschall FurmanOak Ridge Institute for Science and Education (ORISE), Research Participant at U.S. EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, Research Triangle Park, North Carolina 27711, United States.
Michael D HaysCenter for Environmental Measurement and Modeling, Office of Research and Development, U.S. EPA, 109 T.W. Alexander Dr., MD-B105-01, Research Triangle Park, North Carolina 27711, United States.ORCID 0000-0002-4029-8660
Kent W ThomasCenter for Public Health and Environmental Assessment, Office of Research and Development, U.S. EPA, 109 T.W. Alexander Dr., MD-B105-01, Research Triangle Park, North Carolina 27711, United States.
Jane Ellen SimmonsCenter for Public Health and Environmental Assessment, Office of Research and Development, U.S. EPA, 109 T.W. Alexander Dr., MD-B105-01, Research Triangle Park, North Carolina 27711, United States.

Funding

EPA EP-C-13-022EPA EP-C-18-007Intramural EPA EPA999999
6 · The paper itself

Abstract

Trace-level environmental data typically include values near or below detection and quantitation thresholds where health effects may result from low-concentration exposures to one chemical over time or to multiple chemicals. In a cook stove case study, bias in dibenzo[a,h]anthracene concentration means and standard deviations (SDs) was assessed following censoring at thresholds for selected analysis approaches: substituting threshold/2, maximum likelihood estimation, robust regression on order statistics, Kaplan-Meier, and omitting censored observations. Means and SDs for gas chromatography-mass spectrometry-determined concentrations were calculated after censoring at detection and calibration thresholds, 17% and 55% of the data, respectively. Threshold/2 substitution was the least biased. Measurement values were subsequently simulated from two log-normal distributions at two sample sizes. Means and SDs were calculated for 30%, 50%, and 80% censoring levels and compared to known distribution counterparts. Simulation results illustrated (1) threshold/2 substitution to be inferior to modern after-censoring statistical approaches and (2) all after-censoring approaches to be inferior to including all measurement data in analysis. Additionally, differences in stove-specific group means were tested for uncensored samples and after censoring. Group differences of means tests varied depending on censoring and distributional decisions. Investigators should guard against censoring-related bias from (explicit or implicit) distributional and analysis approach decisions.

Indexed as

Models, StatisticalResearch DesignBiasComputer Simulationdetection limitestimating the meanmaximum likelihood estimationnondetectPAHregression on order statisticsreporting levelsimulation study

Identifiers

PMID33625843
PMCPMC8224532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.