Evidence map›Paper›PMID 33625651›Full record

SynthesisInternational ophthalmology2021

Femtosecond laser-assisted implantation of corneal stroma lenticule for keratoconus.

Adriano Fasolo, Alice Galzignato, Emilio Pedrotti, Chiara Chierego, Tiziano Cozzini, Erika Bonacci, Giorgio Marchini

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Applications of SMILE-extracted lenticules in ophthalmology.International journal of ophthalmology · 2024
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Adriano Fasolo *Department of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, U.O.C. di Oculistica-Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Alice Galzignato *Department of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, U.O.C. di Oculistica-Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Emilio PedrottiDepartment of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, U.O.C. di Oculistica-Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy. emilio.pedrotti@univr.it.
Chiara ChieregoDepartment of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, U.O.C. di Oculistica-Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Tiziano CozziniDepartment of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, U.O.C. di Oculistica-Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Erika BonacciDepartment of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, U.O.C. di Oculistica-Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
Giorgio MarchiniDepartment of Neurosciences, Biomedicine and Movement Sciences, Eye Clinic, U.O.C. di Oculistica-Policlinico G.B. Rossi, University of Verona, P.le L.A. Scuro 10, 37134, Verona, Italy.
University of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo review recent progress, challenges, and future perspectives of stromal keratophakia for the treatment of advanced keratoconus.

methodsWe systematically reviewed the literature in the PubMed database, last update June 30, 2020. No language restriction was applied. The authors checked the reference lists of the retrieved articles to identify any additional study of interest.

resultsSeveral techniques have been proposed for the treatment of keratoconus in order to avoid or delay keratoplasty. This was primarily due to the lack of accessibility to donor corneas in many countries. The ease and predictability of the more advanced femtosecond lasers used to correct ametropias by stromal lenticule extraction lead to hypothesize that generated refractive lenticules could be implanted into corneal stromal layers to restore volume and alter the refractive properties of the cornea in patients with corneal ectasias. At the same time, new techniques for preservation, customization, and cellular therapy of the corneal stromal have been developed, directing to the valorization of otherwise discarded byproducts such as donor corneas unsuitable for either lamellar of penetrating keratoplasty.

conclusionsFemtosecond laser-assisted stromal keratophakia could be a suitable therapeutic option for the treatment of corneal ectasias, especially in patients with advanced keratoconus, providing biomechanical support recovering the pachimetry to nearly normal value at the same time. The accuracy and predictability of the refractive outcome are yet a critical issue and the patient eligible for the procedure still has to be characterized.

Indexed as

Corneal Surgery, LaserCorneal TransplantationKeratoconusCorneal StromaCorneal TopographyHumansLasersAdditive keratoplastyCorneal stroma lenticule implantationFemtosecond laserIntrastromal inlayKeratoconusStromal keratophakia

Identifiers

PMID33625651
PMCPMC8087609
OpenAlexW3131027945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.