Trial reportJournal of neurology2021
Trazodone improves obstructive sleep apnea after ischemic stroke: a randomized, double-blind, placebo-controlled, crossover pilot study.
Trial report in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04162743 (The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression), which is not on this map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Trazodone on the Severity of Obstructive Sleep Apnea in Insomnic Stroke Patients With Depression
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Hypnotics on Obstructive Sleep Apnea Severity and Endotypes: A Systematic Review and Meta-Analysis.American journal of respiratory and critical care medicine · 2024Pooled it
- Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2024Pooled it
- Trazodone changed the polysomnographic sleep architecture in insomnia disorder: a systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Endophenotypes of OSA that are responsive to pharmacological agents: a narrative review of trazodone and atomoxetine.Sleep & breathing = Schlaf & Atmung · 2026Review
- Advances in Non-CPAP Management of Obstructive Sleep Apnea: Spotlight on Pharmacological Therapies.Journal of personalized medicine · 2026Review
- Early Screening of Sleep-Disordered Breathing Using a Smartphone-Based Portable System in Stroke Patients and Its Relevance for Rehabilitation: A Prospective Observational Study.Sensors (Basel, Switzerland) · 2026Observational
- Sleep apnea pathophysiology.Sleep & breathing = Schlaf & Atmung · 2023Review
- Unveiling the sleep-cardiovascular connection: Novel perspectives and interventions-A narrative review.Health science reports · 2023Article
- New Metrics from Polysomnography: Precision Medicine for OSA Interventions.Nature and science of sleep · 2023Review
- Shorter respiratory event duration is related to prevalence of type 2 diabetes.Frontiers in endocrinology · 2023Article
- Advances in Molecular Pathology of Obstructive Sleep Apnea.Molecules (Basel, Switzerland) · 2022Review
- Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship.Current neurology and neuroscience reports · 2022Review
- Thyrotropin-releasing hormone analog as a stable upper airway-preferring respiratory stimulant with arousal properties.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Brazilian Academy of Neurology practice guidelines for stroke rehabilitation: part I.Arquivos de neuro-psiquiatria · 2022Article
- Investigating the Neuroprotective and Neuroregenerative Effect of Trazodone Regarding Behavioral Recovery in a BL6C57 Mice Stroke Model.Current health sciences journalArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLow arousal threshold plays a part in the pathogenesis of obstructive sleep apnea (OSA) and may be improved by sedatives. Sedative antidepressants are frequently prescribed for stroke patients due to their high prevalence of insomnia and depression. However, the effect of sedative antidepressants on the severity of OSA in stroke patients has not been studied well.
methodsIn a double-blinded randomized crossover pilot study, 22 post-acute ischemic stroke patients (mean age, 61.7 ± 10.6 y) with OSA received 100 mg of trazodone or a placebo just before polysomnography, with approximately 1 week between measures. The study also measured baseline heart rate variability and 24-h ambulatory blood pressure.
resultsAdministration of trazodone significantly increased the percentage time of slow-wave sleep (31.5 ± 13.2 vs. 18.4 ± 8.7%; P < 0.001) and improved almost all the parameters of OSA severity, including the apnea-hypopnea index (AHI, 25.4 ± 15.4 vs. 39.1 ± 18.4 events/h; P < 0.001), the respiratory arousal index (9.8 (5.8-11.95) vs. 14.1 (11.3-18.7) events/h; P < 0.001), and the minimum oxygen saturation (80.2 ± 9.1 vs. 77.1 ± 9.6%; P = 0.016). Responders to therapy (AHI reduced by > 50%; n = 7/22) had predominant OSA during rapid-eye-movement sleep and decreased sympathetic tone, as reflected in significantly lower mean blood pressure, diastolic blood pressure, and normalized low-frequency power.
conclusionsObstructive sleep apnea with comorbid ischemic stroke may be a distinctive phenotype which responds quite well to trazodone, decreasing OSA severity without increasing nocturnal hypoxia.
trial registrationClinicaltrials.gov: NCT04162743, 2019/11/10.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.