Evidence map›Paper›PMID 33625558›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2021

Amitriptyline functionally antagonizes cardiac H

Joachim Neumann, Maximilian Benedikt Binter, Charlotte Fehse, Margaréta Marušáková, Maren Luise Büxel, Uwe Kirchhefer, Britt Hofmann, Ulrich Gergs

Open access · hybridAbstract read
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Stimulation of histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2025
    Article
  3. Clonidine stimulates force of contraction via histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  4. Lysergic acid diethylamide stimulates cardiac human HNaunyn-Schmiedeberg's archives of pharmacology · 2024
    Article
  5. Review
  6. Ergometrine stimulates histamine HNaunyn-Schmiedeberg's archives of pharmacology · 2023
    Article
  7. Ergotamine Stimulates Human 5-HTInternational journal of molecular sciences · 2023
    Article
  8. Article
  9. The Roles of Cardiovascular HFrontiers in pharmacology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Joachim NeumannInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany.
Maximilian Benedikt BinterInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany.
Charlotte FehseInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany.
Margaréta MarušákováInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany.
Maren Luise BüxelInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany.
Uwe KirchheferInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Westfälische Wilhelms-Universität, Domagkstr. 12, D-48149, Münster, Germany.
Britt HofmannCardiac Surgery, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06120, Halle, Germany.
Ulrich GergsInstitut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther-Universität Halle-Wittenberg, D-06097, Halle, Germany. ulrich.gergs@medizin.uni-halle.de.ORCID 0000-0001-6986-485X
Martin Luther University Halle-Wittenberg · DEUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously shown that histamine (2-(1H-imidazol-4-yl)ethanamine) exerted concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic (H

Indexed as

AmitriptylineAnimalsAntidepressive Agents, TricyclicDose-Response Relationship, DrugHeart AtriaHistamineHistamine H2 AntagonistsHumansMiceMice, TransgenicMyocardial ContractionReceptors, Histamine H2Species SpecificityAmitriptylineAntidepressive Agents, TricyclicHistamineHistamine H2 AntagonistsReceptors, Histamine H2AmitriptylineChronotropyH2-histamine receptorHistamineHuman atriumInotropyPhospholamban phosphorylationTransgenic mice

Identifiers

PMID33625558
PMCPMC8208937
OpenAlexW3131321208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.