Evidence map›Paper›PMID 33625534›Full record

ArticleCalcified tissue international2021

Silencing Proteasome 26S Subunit ATPase 2 (PSMC2) Protects the Osteogenic Differentiation In Vitro and Osteogenesis In Vivo.

Bin Zhou, Kun Peng, Guoqiang Wang, Weihua Chen, Yijun Kang

Abstract read
PubMed Publisher
In one paragraph

Article in Calcified tissue international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Bin Zhou *Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Kun Peng *Department of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Guoqiang WangDepartment of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Weihua ChenDepartment of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Yijun KangDepartment of Spine Surgery, The Second Xiangya Hospital, Central South University, Changsha, 410011, China. kangyijun@csu.edu.cn.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

Innovative Research and Development project of Hunan Development and Reform Commission 2019412
6 · The paper itself

Abstract

Osteoporosis is a commonly seen degenerative bone disorder in the elderly and postmenopausal women, with a low bone mineral density as a major risk factor. The osteogenic potential of bone marrow stromal cells (BMSCs) showed to be impaired during osteoporosis. We established a postmenopausal osteoporosis model in ovariectomized (OVX) mice and found the upregulation of proteasome 26S subunit ATPase 2 (PSMC2) in OVX mice. PSMC2 silencing improved OVX-impaired biomechanical properties of mice femur, OVX-decreased BMD, and OVX-destroyed bone structure. Histopathological analysis indicated that PSMC2 silencing improved bone trabecular structure and increased the contents of collagen fibers and newly formed bone or cartilage in OVX mice. In the meantime, PSMC2 silencing increased Runx2, PI3K, Wnt3a, and β-catenin protein contents while reduced CTSK protein. Within BMSCs isolated from OVX mice, PSMC2 silencing promoted BMSC osteogenic differentiation and elevated osteogenic markers' protein contents, including HOXA10, Runx2, OCN, OPN, and COL1A2. In conclusion, PSMC2 expression is upregulated in the postmenopausal osteoporosis model in OVX mice. PSMC2 silencing promotes the osteogenic differentiation of BMSCs in vitro, promotes bone formation, and inhibits bone resorption in vivo.

Indexed as

ATPases Associated with Diverse Cellular ActivitiesMesenchymal Stem CellsOsteogenesisProteasome Endopeptidase ComplexAdenosine TriphosphatasesAgedAnimalsCell DifferentiationFemaleHumansMiceOvariectomyAdenosine TriphosphatasesATPases Associated with Diverse Cellular ActivitiesProteasome Endopeptidase ComplexPSMC2 protein, humanBone marrow stromal cells (BMSCs)OsteogenesisOsteogenic differentiationOvariectomized (OVX) micePostmenopausal osteoporosisProteasome 26S subunit ATPase 2 (PSMC2)

Identifiers

PMID33625534
OpenAlexW3132960363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.