Evidence map›Paper›PMID 33624923›Full record

ArticleMacromolecular bioscience2021

Electron Beam Sterilization of Poly(Methyl Methacrylate)-Physicochemical and Biological Aspects.

Sina Sharifi, Mohammad Mirazul Islam, Hannah Sharifi, Rakibul Islam, Tahmida N Huq, Per H Nilsson, Tom E Mollnes, Khoa D Tran, Corrina Patzer, Claes H Dohlman and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sina SharifiDisruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.
Mohammad Mirazul IslamDisruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.
Hannah SharifiDisruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.
Rakibul IslamDepartment of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, 0424, Norway.
Tahmida N HuqDepartment of Materials Science and Metallurgy, University of Cambridge, Cambridge, CB3 0FS, UK.
Per H NilssonDepartment of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, 0424, Norway.
Tom E MollnesDepartment of Immunology, Oslo University Hospital, Rikshospitalet, University of Oslo, Oslo, 0424, Norway.
Khoa D TranVision Research Laboratory, Lions VisionGift, Portland, OR, 97214, USA.
Corrina PatzerVision Research Laboratory, Lions VisionGift, Portland, OR, 97214, USA.
Claes H DohlmanDisruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.
Hirak K PatraDepartment of Chemical Engineering and Biotechnology, Cambridge University, Cambridge, CB3 0AS, UK.
Eleftherios I PaschalisDisruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.
Miguel Gonzalez-AndradesDisruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.
James ChodoshDisruptive Technology Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, MA, 02114, USA.ORCID 0000-0002-7463-1599

Funding

Generation of suturable artificial cornea from the integration of exfoliated graphene with gelatin glycidyl methacrylateK99EY030553 · NEI · SCHEPENS EYE RESEARCH INSTITUTE · PI SHARIFI, SINA · 2020 to 2022
$242k
NEI NIH HHS K99 EY030553
6 · The paper itself

Abstract

Electron beam (E-beam) irradiation is an attractive and efficient method for sterilizing clinically implantable medical devices made of natural and/or synthetic materials such as poly(methyl methacrylate) (PMMA). As ionizing irradiation can affect the physicochemical properties of PMMA, understanding the consequences of E-beam sterilization on the intrinsic properties of PMMA is vital for clinical implementation. A detailed assessment of the chemical, optical, mechanical, morphological, and biological properties of medical-grade PMMA after E-beam sterilization at 25 and 50 kiloGray (kGy) is reported. Fourier transform infrared spectroscopy, thermogravimetric analysis, and differential scanning calorimetry studies indicate that E-beam irradiation has minimal effect on the chemical properties of the PMMA at these doses. While 25 kGy irradiation does not alter the mechanical and optical properties of the PMMA, 50 kGy reduces the flexural strength and transparency by 10% and 2%, respectively. Atomic force microscopy demonstrates that E-beam irradiation reduces the surface roughness of PMMA in a dose dependent manner. Live-Dead, AlamarBlue, immunocytochemistry, and complement activation studies show that E-beam irradiation up to 50 kGy has no adverse effect on the biocompatibility of the PMMA. These findings suggest that E-beam irradiation at 25 kGy may be a safe and efficient alternative for PMMA sterilization.

Indexed as

Biocompatible MaterialsCalorimetry, Differential ScanningComplement ActivationCorneaElectronsFibroblastsGamma RaysHumansMicroscopy, Atomic ForcePolymethyl MethacrylateSpectroscopy, Fourier Transform InfraredSterilizationStress, MechanicalSurface PropertiesTemperatureThermogravimetryBiocompatible MaterialsPolymethyl MethacrylateWaterbiocompatibilityelectron beam irradiationpoly(methyl methacrylate)sterilization

Identifiers

PMID33624923
PMCPMC8147572

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.