ArticleSleep2021
Leptin receptor expression in the dorsomedial hypothalamus stimulates breathing during NREM sleep in db/db mice.
Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Circuit Mechanisms Underlying the Contribution of Leptin Receptor-Expressing Neurons in the Nucleus Tractus Solitarius to Ventilatory Homeostasis.Neuroscience bulletin · 2026Article
- Brain-Wide Connectivity and Topographic Organization of Leptin Receptor Neurons in the Dorsomedial Hypothalamus.CNS neuroscience & therapeutics · 2026Article
- Leptin alleviates obesity hypoventilationbioRxiv : the preprint server for biology · 2026Article
- Wakefulness regulation of memory encoding and retrieval: structure and activity.National science review · 2026Review
- Research Progress and Clinical Practice in the Comorbidity Management of Obstructive Sleep Apnea Hypopnea Syndrome and Obesity Hypopnea Syndrome.Diagnostics (Basel, Switzerland) · 2026Review
- Leptin receptor downregulation in the carotid body treats obesity-induced hypertension.Journal of neurophysiology · 2025Article
- Detection of central and obstructive sleep apneas in mice: A new surgical and recording protocol.PloS one · 2025Article
- Leptin signaling in the dorsomedial hypothalamus couples breathing and metabolism in obesity.Cell reports · 2023Article
- On the origins of sleep disordered breathing, cardiorespiratory and metabolic dysfunction: which came first, the chicken or the egg?The Journal of physiology · 2023Article
- Maturational effect of leptin on COPediatric research · 2023Article
- Article
- Oxytocin mediated excitation of hypoglossal motoneurons: implications for treating obstructive sleep apnea.Sleep · 2023Article
- The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state.Frontiers in physiology · 2023Article
- TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies.The Journal of physiology · 2022Article
- Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Review
- The effect of brain serotonin deficiency on breathing is magnified by age.Physiological reports · 2022Article
- Buprenorphine differentially alters breathing among four congenic mouse lines as a function of dose, sex, and leptin status.Respiratory physiology & neurobiology · 2022Article
- Leptin and adiponectin regulate the activity of nuclei involved in sleep-wake cycle in male rats.Frontiers in neuroscience · 2022Article
- Obstructive sleep apnea.Handbook of clinical neurology · 2022Review
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Authors and funding
17 authors.
Funding
Abstract
STUDY
objectivesObesity leads to obstructive sleep apnea (OSA), which is recurrent upper airway obstruction during sleep, and obesity hypoventilation syndrome (OHS), hypoventilation during sleep resulting in daytime hypercapnia. Impaired leptin signaling in the brain was implicated in both conditions, but mechanisms are unknown. We have previously shown that leptin stimulates breathing and treats OSA and OHS in leptin-deficient ob/ob mice and leptin-resistant diet-induced obese mice and that leptin's respiratory effects may occur in the dorsomedial hypothalamus (DMH). We hypothesized that leptin receptor LepRb-deficient db/db mice have obesity hypoventilation and that restoration of leptin signaling in the DMH will increase ventilation during sleep in these animals.
methodsWe measured arterial blood gas in unanesthetized awake db/db mice. We subsequently infected these animals with Ad-LepRb or control Ad-mCherry virus into the DMH and measured ventilation during sleep as well as CO2 production after intracerebroventricular (ICV) infusions of phosphate-buffered saline or leptin.
resultsAwake db/db mice had elevated CO2 levels in the arterial blood. Ad-LepRb infection resulted in LepRb expression in the DMH neurons in a similar fashion to wildtype mice. In LepRb-DMH db/db mice, ICV leptin shortened REM sleep and increased inspiratory flow, tidal volume, and minute ventilation during NREM sleep without any effect on the quality of NREM sleep or CO2 production. Leptin had no effect on upper airway obstruction in these animals.
conclusionLeptin stimulates breathing and treats obesity hypoventilation acting on LepRb-positive neurons in the DMH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.