ArticleJournal of neural engineering2021
The Argo: a high channel count recording system for neural recording in vivo.
Article in Journal of neural engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed.
- A Dual-Mode Neural Amplifier Array for Biopotential and FSCV-Based Neurochemical Measurements.Biosensors · 2026Article
- Cytoarchitecture and myeloarchitecture of the sheep auditory cortex.Journal of anatomy · 2026Article
- A Thin Film Transistor Backplane for Scalable Chronic Neural Interfaces.bioRxiv : the preprint server for biology · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation.Nature biomedical engineering · 2026Article
- A Framework for Compressive On-Chip Action Potential Recording.IEEE transactions on bio-medical engineering · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Enhanced sensory perception and myoelectric control with high channel count implanted sensorimotor systems.Journal of neural engineering · 2025Article
- Finite element model predicts micromotion-induced strain profiles that correlate with the functional performance of Utah arrays in humans and non-human primates.Journal of neural engineering · 2025Article
- Iris 128x: open-source 128 channel headstages for neural stimulation and recording.Journal of neural engineering · 2025Article
- Chronic alteration of CabioRxiv : the preprint server for biology · 2025Article
- Bidirectional mechanisms and emerging strategies for implantable bioelectronic interfaces.Bioactive materials · 2025Review
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- Fabrication and Dose-Response Simulation of Soft Dual-Sided Deep Brain Stimulation Electrode.Micromachines · 2025Article
- Monolithic three-dimensional neural probes from deterministic rolling of soft electronics.Nature electronics · 2025Article
- Capturing the Electrical Activity of all Cortical Neurons: Are Solutions Within Reach?Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Long-term performance of intracortical microelectrode arrays in 14 BrainGate clinical trial participants.medRxiv : the preprint server for health sciences · 2025Article
- Article
- A novel robot-assisted method for implanting intracortical sensorimotor devices for brain-computer interface studies: principles, surgical techniques, and challenges.Journal of neurosurgery · 2025Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors.
Funding
Abstract
objectiveDecoding neural activity has been limited by the lack of tools available to record from large numbers of neurons across multiple cortical regions simultaneously with high temporal fidelity. To this end, we developed the Argo system to record cortical neural activity at high data rates. APPROACH: Here we demonstrate a massively parallel neural recording system based on platinum-iridium microwire electrode arrays bonded to a CMOS voltage amplifier array. The Argo system is the highest channel count in vivo neural recording system, supporting simultaneous recording from 65 536 channels, sampled at 32 kHz and 12-bit resolution. This system was designed for cortical recordings, compatible with both penetrating and surface microelectrodes. MAIN
resultsWe validated this system through initial bench testing to determine specific gain and noise characteristics of bonded microwires, followed by in-vivo experiments in both rat and sheep cortex. We recorded spiking activity from 791 neurons in rats and surface local field potential activity from over 30 000 channels in sheep. SIGNIFICANCE: These are the largest channel count microwire-based recordings in both rat and sheep. While currently adapted for head-fixed recording, the microwire-CMOS architecture is well suited for clinical translation. Thus, this demonstration helps pave the way for a future high data rate intracortical implant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.