ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2021
[Investigating the causal relationship between human blood metabolites and coronary artery disease using two-sample Mendelian randomization].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Glaucoma and cardiovascular disease: a bidirectional two-sample Mendelian randomization analysis.Experimental biology and medicine (Maywood, N.J.) · 2025Article
- [Aldehyde dehydrogenase 2 rs671 genetic polymorphisms are associated with chemotherapy-induced nausea and vomiting].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- The genetic architecture of blood pressure variability: A genome-wide association study of 9370 participants from UK Biobank.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
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Authors and funding
3 authors.
Funding
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Abstract
objectiveTo explore the causal relationship between blood metabolites and the risk of coronary artery disease (CAD) using a two-sample Mendelian randomization (MR) approach.
objectiveBased on the data from a large-scale metabolome-based genome-wide association study (mGWAS) and the GWAS of CAD, we investigated the causality between blood metabolites and CAD using an inverse variance weighted (IVW) method and another 4 two-sample MR models. Heterogeneity, horizontal pleiotropy, and sensitivity tests were performed to evaluate the stability and reliability of the results.
objectiveAmong the 486 blood metabolites, 32 metabolites showed nominally causative association with CAD with the IVW method (
objectiveThere is no strong evidence to support a robust causal relationship between the 486 blood metabolites and the risk of CAD.
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Registered trials
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