Evidence map›Paper›PMID 33624527›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2021

Transcutaneous auricular vagal nerve stimulation improves functional dyspepsia by enhancing vagal efferent activity.

Ying Zhu, Feng Xu, Dewen Lu, Peijing Rong, Jiafei Cheng, Miaomiao Li, Yaoyao Gong, Chao Sun, Wei Wei, Lin Lin and 1 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06597149 (Effect of Transcutaneous Auricular Vagus Nerve Stimulation), which is not on this map. Cited by 70 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 4 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06597149 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Plasma Insulin Levels

TypeinterventionalSponsorIndiana UniversityRan2025 to 2028Enrolled30ConditionsHealthyArmsTranscutaneous Auricular Vagus Nerve Stimulation
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 4 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Ying ZhuDivision of Gastroenterology, Northern Jiangsu People's Hospital, Yangzhou, China.ORCID 0000-0001-9880-5330
Feng XuDivision of Gastroenterology, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, China.
Dewen LuDivision of Gastroenterology, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, China.
Peijing RongInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Jiafei ChengDivision of Gastroenterology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.ORCID 0000-0003-4083-8150
Miaomiao LiDivision of Gastroenterology, the Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, China.
Yaoyao GongDivision of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chao SunDivision of Gastroenterology, Northern Jiangsu People's Hospital, Yangzhou, China.
Wei WeiDivision of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Lin LinDivision of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Jiande D Z ChenDivision of Gastroenterology and Hepatology, School of Medicine, University of Michigan, Ann Arbor, Michigan.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNJiangsu Province Hospital · CNNingbo University · CNNorthern Jiangsu People's Hospital · CNHuaian First People’s Hospital · CNNanjing University of Chinese Medicine · CNUniversity of Michigan · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5M
NIDDK NIH HHS P30 DK034933
6 · The paper itself

Abstract

This study was designed to investigate whether transcutaneous auricular vagal nerve stimulation (taVNS) would be able to improve major pathophysiologies of functional dyspepsia (FD) in patients with FD. Thirty-six patients with FD (21 F) were studied in two sessions (taVNS and sham-ES). Physiological measurements, including gastric slow waves, gastric accommodation, and autonomic functions, were assessed by the electrogastrogram (EGG), a nutrient drink test and the spectral analysis of heart rate variability derived from the electrocardiogram (ECG), respectively. Thirty-six patients with FD (25 F) were randomized to receive 2-wk taVNS or sham-ES. The dyspeptic symptom scales, anxiety and depression scores, and the same physiological measurements were assessed at the beginning and the end of the 2-wk treatment. In comparison with sham-ES, acute taVNS improved gastric accommodation (

Indexed as

AdolescentAdultAgedAutonomic Nervous SystemDyspepsiaFemaleGastric EmptyingGastrointestinal MotilityHumansMaleMiddle AgedStomachTreatment OutcomeVagus NerveVagus Nerve StimulationYoung Adultfunctional dyspepsiagastric accommodationgastrointestinal motilityvagal nerve stimulationvisceral pain

Identifiers

PMID33624527
PMCPMC8887908
OpenAlexW3133225900

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.