Evidence map›Paper›PMID 33624269›Full record

ReviewJournal of microbiology (Seoul, Korea)2021

Minor and major circRNAs in virus and host genomes.

Zhihao Lou, Rui Zhou, Yinghua Su, Chun Liu, Wenting Ruan, Che Ok Jeon, Xiao Han, Chun Lin, Baolei Jia

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of microbiology (Seoul, Korea), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhihao Lou *College of Biological Science and Engineering, Fuzhou University, Fujian, 350108, P. R. China.
Rui Zhou *Mengchao Hepatobiliary Hospital of Fujian Medical University, Fujian, 350108, P. R. China.
Yinghua SuCollege of Biological Science and Engineering, Fuzhou University, Fujian, 350108, P. R. China.
Chun LiuCollege of Biological Science and Engineering, Fuzhou University, Fujian, 350108, P. R. China.
Wenting RuanDepartment of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea.
Che Ok JeonDepartment of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea.
Xiao HanCollege of Biological Science and Engineering, Fuzhou University, Fujian, 350108, P. R. China. hanxiao@fzu.edu.cn.
Chun LinMengchao Hepatobiliary Hospital of Fujian Medical University, Fujian, 350108, P. R. China. linchun200707@126.com.
Baolei JiaDepartment of Life Science, Chung-Ang University, Seoul, 06974, Republic of Korea. baoleijia@cau.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As a special type of noncoding RNA, circular RNAs (circRNAs) are prevalent in many organisms. They can serve as sponges for microRNAs and protein scaffolds, or templates for protein translation, making them linked to cellular homeostasis and disease progression. In recent years, circRNAs have been found to be abnormally expressed during the processes of viral infection and pathogenesis, and can help a virus escape the immune response of a host. Thus, they are now considered to play important functions in the invasion and development of viruses. Moreover, the potential application of circRNAs as biomarkers of viral infection or candidates for therapeutic targeting deserves consideration. This review summarizes circRNAs in the transcriptome, including their classification, production, functions, and value as biomarkers. This review paper also describes research progress on circRNAs in viral infection (mainly hepatitis B virus, HIV, and some human herpes viruses) and aims to provide new ideas for antiviral therapies targeting circRNAs.

Indexed as

AnimalsGenome, ViralHumansMicroRNAsRNA, CircularRNA, ViralVirus DiseasesVirusesMicroRNAsRNA, CircularRNA, ViralcircRNAsHBVHIVncRNAsvirus

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.